Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.

Dongyu Min; Xiaoyuan Mao; Kuncan Wu; Yonggang Cao; Feng Guo; Shu Zhu; Ni Xie; Lei Wang; Tianbao Chen; Chris Shaw; Jiqun Cai

doi:10.1016/j.neulet.2011.12.064

Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.

Dongyu Min, Xiaoyuan Mao, Kuncan Wu, Yonggang Cao, Feng Guo, Shu Zhu, Ni Xie, Lei Wang, Tianbao Chen, Chris Shaw, Jiqun Cai

Queen's University Belfast

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Decreased cerebral blood flow causes cognitive impairments and neuronal injury in vascular dementia. In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils. Treatment with 5mg/kg of donepezil for 21 consecutive days following a 10-min period of ischemia significantly inhibited delayed neuronal death in the hippocampal CA1 region. In Morris water maze test, memory impairment was significantly improved by donepezil treatment. Western blot analysis showed that donepezil treatment prevented reductions in p-CaMKII and p-CREB protein levels in the hippocampus. These results suggest that donepezil attenuates the memory deficit induced by transient global cerebral ischemia and this neuroprotection may be associated with the phosphorylation of CaMKII and CERB in the hippocampus.
Highlights
► Memory impairment was improved in ischemia gerbils treated with donepezil. ► Donepezil inhibited neuronal death in the hippocampal CA1 region in ischemic gerbils. ► Donepezil increased p-CaMKII and p-CREB protein levels in ischemic gerbils.

Original language	English
Pages (from-to)	29-33
Number of pages	5
Journal	Neuroscience Letters
Volume	510
Issue number	1
Early online date	08 Jan 2012
DOIs	https://doi.org/10.1016/j.neulet.2011.12.064
Publication status	Published - 21 Feb 2012

ASJC Scopus subject areas

Neuroscience(all)

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title = "Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.",

abstract = "Decreased cerebral blood flow causes cognitive impairments and neuronal injury in vascular dementia. In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils. Treatment with 5mg/kg of donepezil for 21 consecutive days following a 10-min period of ischemia significantly inhibited delayed neuronal death in the hippocampal CA1 region. In Morris water maze test, memory impairment was significantly improved by donepezil treatment. Western blot analysis showed that donepezil treatment prevented reductions in p-CaMKII and p-CREB protein levels in the hippocampus. These results suggest that donepezil attenuates the memory deficit induced by transient global cerebral ischemia and this neuroprotection may be associated with the phosphorylation of CaMKII and CERB in the hippocampus.Highlights► Memory impairment was improved in ischemia gerbils treated with donepezil. ► Donepezil inhibited neuronal death in the hippocampal CA1 region in ischemic gerbils. ► Donepezil increased p-CaMKII and p-CREB protein levels in ischemic gerbils.",

author = "Dongyu Min and Xiaoyuan Mao and Kuncan Wu and Yonggang Cao and Feng Guo and Shu Zhu and Ni Xie and Lei Wang and Tianbao Chen and Chris Shaw and Jiqun Cai",

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language = "English",

volume = "510",

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journal = "Neuroscience Letters",

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Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils. / Min, Dongyu; Mao, Xiaoyuan; Wu, Kuncan; Cao, Yonggang; Guo, Feng; Zhu, Shu; Xie, Ni; Wang, Lei ; Chen, Tianbao ; Shaw, Chris; Cai, Jiqun.

In: Neuroscience Letters, Vol. 510, No. 1, 21.02.2012, p. 29-33.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.

AU - Min, Dongyu

AU - Mao, Xiaoyuan

AU - Wu, Kuncan

AU - Cao, Yonggang

AU - Guo, Feng

AU - Zhu, Shu

AU - Xie, Ni

AU - Wang, Lei

AU - Chen, Tianbao

AU - Shaw, Chris

AU - Cai, Jiqun

PY - 2012/2/21

Y1 - 2012/2/21

N2 - Decreased cerebral blood flow causes cognitive impairments and neuronal injury in vascular dementia. In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils. Treatment with 5mg/kg of donepezil for 21 consecutive days following a 10-min period of ischemia significantly inhibited delayed neuronal death in the hippocampal CA1 region. In Morris water maze test, memory impairment was significantly improved by donepezil treatment. Western blot analysis showed that donepezil treatment prevented reductions in p-CaMKII and p-CREB protein levels in the hippocampus. These results suggest that donepezil attenuates the memory deficit induced by transient global cerebral ischemia and this neuroprotection may be associated with the phosphorylation of CaMKII and CERB in the hippocampus.Highlights► Memory impairment was improved in ischemia gerbils treated with donepezil. ► Donepezil inhibited neuronal death in the hippocampal CA1 region in ischemic gerbils. ► Donepezil increased p-CaMKII and p-CREB protein levels in ischemic gerbils.

AB - Decreased cerebral blood flow causes cognitive impairments and neuronal injury in vascular dementia. In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils. Treatment with 5mg/kg of donepezil for 21 consecutive days following a 10-min period of ischemia significantly inhibited delayed neuronal death in the hippocampal CA1 region. In Morris water maze test, memory impairment was significantly improved by donepezil treatment. Western blot analysis showed that donepezil treatment prevented reductions in p-CaMKII and p-CREB protein levels in the hippocampus. These results suggest that donepezil attenuates the memory deficit induced by transient global cerebral ischemia and this neuroprotection may be associated with the phosphorylation of CaMKII and CERB in the hippocampus.Highlights► Memory impairment was improved in ischemia gerbils treated with donepezil. ► Donepezil inhibited neuronal death in the hippocampal CA1 region in ischemic gerbils. ► Donepezil increased p-CaMKII and p-CREB protein levels in ischemic gerbils.

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SN - 0304-3940

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Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.

Abstract

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