Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.

Dongyu Min, Xiaoyuan Mao, Kuncan Wu, Yonggang Cao, Feng Guo, Shu Zhu, Ni Xie, Lei Wang, Tianbao Chen, Chris Shaw, Jiqun Cai

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Decreased cerebral blood flow causes cognitive impairments and neuronal injury in vascular dementia. In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils. Treatment with 5mg/kg of donepezil for 21 consecutive days following a 10-min period of ischemia significantly inhibited delayed neuronal death in the hippocampal CA1 region. In Morris water maze test, memory impairment was significantly improved by donepezil treatment. Western blot analysis showed that donepezil treatment prevented reductions in p-CaMKII and p-CREB protein levels in the hippocampus. These results suggest that donepezil attenuates the memory deficit induced by transient global cerebral ischemia and this neuroprotection may be associated with the phosphorylation of CaMKII and CERB in the hippocampus.
Highlights
► Memory impairment was improved in ischemia gerbils treated with donepezil. ► Donepezil inhibited neuronal death in the hippocampal CA1 region in ischemic gerbils. ► Donepezil increased p-CaMKII and p-CREB protein levels in ischemic gerbils.
Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalNeuroscience Letters
Volume510
Issue number1
Early online date08 Jan 2012
DOIs
Publication statusPublished - 21 Feb 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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