Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

Richard Clarke; J Frost; P. Sherliker; S. Lewington; Rodger Collins; L. Brattstrom; I. Brouwer; M. Van Dusseldorp; R.P.M. Steegers-Theunissen; Geraldine Cuskelly; Michael Ward; Mark McNulty; June Scott; M. Den Heijer; H. Blom; N. Van Der Put; C.J. Shorah; M.R. Malinow; Joseph McMahon; J. Tobert; D. Kush; E. Joosten; R. Riezier; K. Pietrzik; J. Dierkes; A. Bronstrup; P. Jacques; Madeline Mason; I. Rosenberg; J. Thambyrajah; M. Landray; J. Townend; Marcus Wheeler; J. Ubbink; F. Van Oort; A. Melse-Boonstra; P. Verhoef; Jayne Woodside; John Yarnell; Ian Young; Alun Evans; D. Wald; K Law; N. Wald

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

Richard Clarke, J Frost, P. Sherliker, S. Lewington, Rodger Collins, L. Brattstrom, I. Brouwer, M. Van Dusseldorp, R.P.M. Steegers-Theunissen, Geraldine Cuskelly, Michael Ward, Mark McNulty, June Scott, M. Den Heijer, H. Blom, N. Van Der Put, C.J. Shorah, M.R. Malinow, Joseph McMahon, J. TobertD. Kush, E. Joosten, R. Riezier, K. Pietrzik, J. Dierkes, A. Bronstrup, P. Jacques, Madeline Mason, I. Rosenberg, J. Thambyrajah, M. Landray, J. Townend, Marcus Wheeler, J. Ubbink, F. Van Oort, A. Melse-Boonstra, P. Verhoef, Jayne Woodside, John Yarnell, Ian Young, Alun Evans, D. Wald, K Law, N. Wald

Research output: Contribution to journal › Article › peer-review

357 Citations (Scopus)

Abstract

Background: Dietary supplementation with B vitamins that lower blood homocysteine concentrations is expected to reduce cardiovascular disease risk, but there has been uncertainty about the optimum regimen to use for this purpose.

Original language	English
Pages (from-to)	806-812
Number of pages	7
Journal	American Journal of Clinical Nutrition
Volume	82
Issue number	4
Publication status	Published - 2005

ASJC Scopus subject areas

Medicine (miscellaneous)
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Clarke, R., Frost, J., Sherliker, P., Lewington, S., Collins, R., Brattstrom, L., Brouwer, I., Van Dusseldorp, M., Steegers-Theunissen, R. P. M., Cuskelly, G., Ward, M., McNulty, M., Scott, J., Den Heijer, M., Blom, H., Van Der Put, N., Shorah, C. J., Malinow, M. R., McMahon, J., ... Wald, N. (2005). Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. American Journal of Clinical Nutrition, 82(4), 806-812.

Clarke, Richard ; Frost, J ; Sherliker, P. ; Lewington, S. ; Collins, Rodger ; Brattstrom, L. ; Brouwer, I. ; Van Dusseldorp, M. ; Steegers-Theunissen, R.P.M. ; Cuskelly, Geraldine ; Ward, Michael ; McNulty, Mark ; Scott, June ; Den Heijer, M. ; Blom, H. ; Van Der Put, N. ; Shorah, C.J. ; Malinow, M.R. ; McMahon, Joseph ; Tobert, J. ; Kush, D. ; Joosten, E. ; Riezier, R. ; Pietrzik, K. ; Dierkes, J. ; Bronstrup, A. ; Jacques, P. ; Mason, Madeline ; Rosenberg, I. ; Thambyrajah, J. ; Landray, M. ; Townend, J. ; Wheeler, Marcus ; Ubbink, J. ; Van Oort, F. ; Melse-Boonstra, A. ; Verhoef, P. ; Woodside, Jayne ; Yarnell, John ; Young, Ian ; Evans, Alun ; Wald, D. ; Law, K ; Wald, N. / Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. In: American Journal of Clinical Nutrition. 2005 ; Vol. 82, No. 4. pp. 806-812.

@article{5ecaf910465f41f190549277c0fbcb59,

title = "Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials",

abstract = "Background: Dietary supplementation with B vitamins that lower blood homocysteine concentrations is expected to reduce cardiovascular disease risk, but there has been uncertainty about the optimum regimen to use for this purpose.",

author = "Richard Clarke and J Frost and P. Sherliker and S. Lewington and Rodger Collins and L. Brattstrom and I. Brouwer and {Van Dusseldorp}, M. and R.P.M. Steegers-Theunissen and Geraldine Cuskelly and Michael Ward and Mark McNulty and June Scott and {Den Heijer}, M. and H. Blom and {Van Der Put}, N. and C.J. Shorah and M.R. Malinow and Joseph McMahon and J. Tobert and D. Kush and E. Joosten and R. Riezier and K. Pietrzik and J. Dierkes and A. Bronstrup and P. Jacques and Madeline Mason and I. Rosenberg and J. Thambyrajah and M. Landray and J. Townend and Marcus Wheeler and J. Ubbink and {Van Oort}, F. and A. Melse-Boonstra and P. Verhoef and Jayne Woodside and John Yarnell and Ian Young and Alun Evans and D. Wald and K Law and N. Wald",

year = "2005",

language = "English",

volume = "82",

pages = "806--812",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "4",

}

Clarke, R, Frost, J, Sherliker, P, Lewington, S, Collins, R, Brattstrom, L, Brouwer, I, Van Dusseldorp, M, Steegers-Theunissen, RPM, Cuskelly, G, Ward, M, McNulty, M, Scott, J, Den Heijer, M, Blom, H, Van Der Put, N, Shorah, CJ, Malinow, MR, McMahon, J, Tobert, J, Kush, D, Joosten, E, Riezier, R, Pietrzik, K, Dierkes, J, Bronstrup, A, Jacques, P, Mason, M, Rosenberg, I, Thambyrajah, J, Landray, M, Townend, J, Wheeler, M, Ubbink, J, Van Oort, F, Melse-Boonstra, A, Verhoef, P, Woodside, J, Yarnell, J, Young, I, Evans, A, Wald, D, Law, K & Wald, N 2005, 'Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials', American Journal of Clinical Nutrition, vol. 82, no. 4, pp. 806-812.

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. / Clarke, Richard; Frost, J; Sherliker, P.; Lewington, S.; Collins, Rodger; Brattstrom, L.; Brouwer, I.; Van Dusseldorp, M.; Steegers-Theunissen, R.P.M.; Cuskelly, Geraldine; Ward, Michael; McNulty, Mark; Scott, June; Den Heijer, M.; Blom, H.; Van Der Put, N.; Shorah, C.J.; Malinow, M.R.; McMahon, Joseph; Tobert, J.; Kush, D.; Joosten, E.; Riezier, R.; Pietrzik, K.; Dierkes, J.; Bronstrup, A.; Jacques, P.; Mason, Madeline; Rosenberg, I.; Thambyrajah, J.; Landray, M.; Townend, J.; Wheeler, Marcus; Ubbink, J.; Van Oort, F.; Melse-Boonstra, A.; Verhoef, P.; Woodside, Jayne; Yarnell, John; Young, Ian; Evans, Alun; Wald, D.; Law, K; Wald, N.

In: American Journal of Clinical Nutrition, Vol. 82, No. 4, 2005, p. 806-812.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

AU - Clarke, Richard

AU - Frost, J

AU - Sherliker, P.

AU - Lewington, S.

AU - Collins, Rodger

AU - Brattstrom, L.

AU - Brouwer, I.

AU - Van Dusseldorp, M.

AU - Steegers-Theunissen, R.P.M.

AU - Cuskelly, Geraldine

AU - Ward, Michael

AU - McNulty, Mark

AU - Scott, June

AU - Den Heijer, M.

AU - Blom, H.

AU - Van Der Put, N.

AU - Shorah, C.J.

AU - Malinow, M.R.

AU - McMahon, Joseph

AU - Tobert, J.

AU - Kush, D.

AU - Joosten, E.

AU - Riezier, R.

AU - Pietrzik, K.

AU - Dierkes, J.

AU - Bronstrup, A.

AU - Jacques, P.

AU - Mason, Madeline

AU - Rosenberg, I.

AU - Thambyrajah, J.

AU - Landray, M.

AU - Townend, J.

AU - Wheeler, Marcus

AU - Ubbink, J.

AU - Van Oort, F.

AU - Melse-Boonstra, A.

AU - Verhoef, P.

AU - Woodside, Jayne

AU - Yarnell, John

AU - Young, Ian

AU - Evans, Alun

AU - Wald, D.

AU - Law, K

AU - Wald, N.

PY - 2005

Y1 - 2005

N2 - Background: Dietary supplementation with B vitamins that lower blood homocysteine concentrations is expected to reduce cardiovascular disease risk, but there has been uncertainty about the optimum regimen to use for this purpose.

AB - Background: Dietary supplementation with B vitamins that lower blood homocysteine concentrations is expected to reduce cardiovascular disease risk, but there has been uncertainty about the optimum regimen to use for this purpose.

M3 - Article

VL - 82

SP - 806

EP - 812

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 4

ER -

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

Abstract

ASJC Scopus subject areas

UN SDGs

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