Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

Richard Clarke, J Frost, P. Sherliker, S. Lewington, Rodger Collins, L. Brattstrom, I. Brouwer, M. Van Dusseldorp, R.P.M. Steegers-Theunissen, Geraldine Cuskelly, Michael Ward, Mark McNulty, June Scott, M. Den Heijer, H. Blom, N. Van Der Put, C.J. Shorah, M.R. Malinow, Joseph McMahon, J. TobertD. Kush, E. Joosten, R. Riezier, K. Pietrzik, J. Dierkes, A. Bronstrup, P. Jacques, Madeline Mason, I. Rosenberg, J. Thambyrajah, M. Landray, J. Townend, Marcus Wheeler, J. Ubbink, F. Van Oort, A. Melse-Boonstra, P. Verhoef, Jayne Woodside, John Yarnell, Ian Young, Alun Evans, D. Wald, K Law, N. Wald

Research output: Contribution to journalArticlepeer-review

357 Citations (Scopus)

Abstract

Background: Dietary supplementation with B vitamins that lower blood homocysteine concentrations is expected to reduce cardiovascular disease risk, but there has been uncertainty about the optimum regimen to use for this purpose.
Original languageEnglish
Pages (from-to)806-812
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume82
Issue number4
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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