Abstract
Although, ionizing radiation (IR) has been implicated to cause stress in endoplasmic reticulum (ER), how ER stress signaling and major ER stress sensors modulate cellular response to IR is unclear. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an ER transmembrane protein which initiates unfolded protein response (UPR) or ER stress signaling when ER homeostasis is disturbed. Here, we report that down-regulation of PERK resulted in increased clonogenic survival, enhanced DNA repair and reduced apoptosis in irradiated cancer cells. Our study demonstrated that PERK has a role in sensitizing cancer cells to IR.
| Original language | English |
|---|---|
| Pages (from-to) | 31-35 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 441 |
| Issue number | 1 |
| Early online date | 05 Oct 2013 |
| DOIs | |
| Publication status | Published - 08 Nov 2013 |
Keywords
- PERK
- Ionizing radiation
- DNA damage
- ER-stress
- ENDOPLASMIC-RETICULUM STRESS
- UNFOLDED PROTEIN RESPONSE
- INDUCED APOPTOSIS
- SIGNALING PATHWAYS
- DNA-DAMAGE
- MAMMALIAN-CELLS
- BREAST-CANCER
- TRANSLATION
- KINASE
- PHOSPHORYLATION
Access to Document
- Down-regulation of PERK enhances resistance to ionizing radiation
© 2013 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/,which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.