Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

A.V. Pointon, T.M. Walker, K.M. Phillips, J.L. Luo, J. Riley, Shu-Dong Zhang, J.D. Parry, J.J. Lyon, E.L. Marczylo, T.W. Gant

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background: Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cycling compound due to its low redox potential. Here we used genomic and chemical systems approaches in vivo to investigate the mechanisms of doxorubicin cardiotoxicity, and specifically test the hypothesis of redox cycling mediated cardiotoxicity.
Original languageEnglish
Article number12733
Pages (from-to)1-17
Number of pages17
JournalPLoS ONE
Volume5
Issue number9
DOIs
Publication statusPublished - Sep 2010

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Pointon, A. V., Walker, T. M., Phillips, K. M., Luo, J. L., Riley, J., Zhang, S-D., Parry, J. D., Lyon, J. J., Marczylo, E. L., & Gant, T. W. (2010). Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. PLoS ONE, 5(9), 1-17. [12733]. https://doi.org/10.1371/journal.pone.0012733