Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

A.V. Pointon; T.M. Walker; K.M. Phillips; J.L. Luo; J. Riley; Shu-Dong Zhang; J.D. Parry; J.J. Lyon; E.L. Marczylo; T.W. Gant

doi:10.1371/journal.pone.0012733

Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

A.V. Pointon, T.M. Walker, K.M. Phillips, J.L. Luo, J. Riley, Shu-Dong Zhang, J.D. Parry, J.J. Lyon, E.L. Marczylo, T.W. Gant

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Background: Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cycling compound due to its low redox potential. Here we used genomic and chemical systems approaches in vivo to investigate the mechanisms of doxorubicin cardiotoxicity, and specifically test the hypothesis of redox cycling mediated cardiotoxicity.

Original language	English
Article number	12733
Pages (from-to)	1-17
Number of pages	17
Journal	PLoS ONE
Volume	5
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0012733
Publication status	Published - Sep 2010

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

UN SDGs

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10.1371/journal.pone.0012733

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Pointon, A. V., Walker, T. M., Phillips, K. M., Luo, J. L., Riley, J., Zhang, S-D., Parry, J. D., Lyon, J. J., Marczylo, E. L., & Gant, T. W. (2010). Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. PLoS ONE, 5(9), 1-17. [12733]. https://doi.org/10.1371/journal.pone.0012733

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Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. / Pointon, A.V.; Walker, T.M.; Phillips, K.M.; Luo, J.L.; Riley, J.; Zhang, Shu-Dong; Parry, J.D.; Lyon, J.J.; Marczylo, E.L.; Gant, T.W.

In: PLoS ONE, Vol. 5, No. 9, 12733, 09.2010, p. 1-17.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Pointon, A.V.

AU - Walker, T.M.

AU - Phillips, K.M.

AU - Luo, J.L.

AU - Riley, J.

AU - Zhang, Shu-Dong

AU - Parry, J.D.

AU - Lyon, J.J.

AU - Marczylo, E.L.

AU - Gant, T.W.

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AB - Background: Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cycling compound due to its low redox potential. Here we used genomic and chemical systems approaches in vivo to investigate the mechanisms of doxorubicin cardiotoxicity, and specifically test the hypothesis of redox cycling mediated cardiotoxicity.

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DO - 10.1371/journal.pone.0012733

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Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

Abstract

ASJC Scopus subject areas

UN SDGs

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