Dual stimuli-responsive hydrogels for colon targeted drug delivery

Mohmmad Imad Rabeh; Colin P McCoy; Matthew Wylie

doi:10.5920/bjpharm.1134

Dual stimuli-responsive hydrogels for colon targeted drug delivery

Mohmmad Imad Rabeh, Colin P McCoy, Matthew Wylie

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

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Abstract

Colon targeted drug delivery systems are promising for the treatment of local diseases. The colon possesses a diverse microbiome that secretes a number of biomolecules, such as enzymes, that can be exploited for targeted drug delivery. Here, we report the synthesis of 2-hydroxyethyl methacrylate and methacrylic acid copolymer hydrogels crosslinked with an enzyme-sensitive crosslinking agent. The swelling and drug release properties of hydrogels were observed in pH 1.2, pH 6.5 and pH 7.4, and in the presence of rat cecal content. Swelling studies revealed pH responsivity of the hydrogels while the release kinetics of metronidazole from hydrogels containing an enzyme-labile crosslinker were faster in the presence of rat cecal content. The results show that dual responsive hydrogels could provide a promising platform for colonic drug delivery.

Original language	English
Article number	1134
Pages (from-to)	S1-S2
Number of pages	2
Journal	British Journal of Pharmacy
Volume	7
Issue number	2
Early online date	04 Nov 2022
DOIs	https://doi.org/10.5920/bjpharm.1134
Publication status	Early online date - 04 Nov 2022

Keywords

Management Science and Operations Research
Mechanical Engineering
Energy Engineering and Power Technology

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10.5920/bjpharm.1134Licence: CC BY

Dual stimuli-responsive hydrogels for colon targeted drug delivery
© 2022 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 384 KBLicence: CC BY

13th Academy of Pharmaceutical Sciences International PharmSci Conference 2022
Rabeh, M. (Participant), McCoy, C. (Advisor) & Wylie, M. (Advisor)
07 Sept 2022 → 09 Sept 2022
Activity: Participating in or organising an event types › Participation in conference

Stimuli-responsive hydrogels for site-specific drug delivery
Rabeh, M. (Author), McCoy, C. (Supervisor) & Wylie, M. (Supervisor), Jul 2024
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

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abstract = "Colon targeted drug delivery systems are promising for the treatment of local diseases. The colon possesses a diverse microbiome that secretes a number of biomolecules, such as enzymes, that can be exploited for targeted drug delivery. Here, we report the synthesis of 2-hydroxyethyl methacrylate and methacrylic acid copolymer hydrogels crosslinked with an enzyme-sensitive crosslinking agent. The swelling and drug release properties of hydrogels were observed in pH 1.2, pH 6.5 and pH 7.4, and in the presence of rat cecal content. Swelling studies revealed pH responsivity of the hydrogels while the release kinetics of metronidazole from hydrogels containing an enzyme-labile crosslinker were faster in the presence of rat cecal content. The results show that dual responsive hydrogels could provide a promising platform for colonic drug delivery.",

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AU - Rabeh, Mohmmad Imad

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Dual stimuli-responsive hydrogels for colon targeted drug delivery

Abstract

Keywords

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Activities

13th Academy of Pharmaceutical Sciences International PharmSci Conference 2022

Student theses

Stimuli-responsive hydrogels for site-specific drug delivery

Cite this