Duplicate retention in signalling proteins and constraints from network dynamics

O. S. Soyer*, C. J. Creevey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Duplications are a major driving force behind evolution. Most duplicates are believed to fix through genetic drift, but it is not clear whether this process affects all duplications equally or whether there are certain gene families that are expected to show neutral expansions under certain circumstances. Here, we analyse the neutrality of duplications in different functional classes of signalling proteins based on their effects on response dynamics. We find that duplications involving intermediary proteins in a signalling network are neutral more often than those involving receptors. Although the fraction of neutral duplications in all functional classes increase with decreasing population size and selective pressure on dynamics, this effect is most pronounced for receptors, indicating a possible expansion of receptors in species with small population size. In line with such an expectation, we found a statistically significant increase in the number of receptors as a fraction of genome size in eukaryotes compared with prokaryotes. Although not confirmative, these results indicate that neutral processes can be a significant factor in shaping signalling networks and affect proteins from different functional classes differently.

Original languageEnglish
Pages (from-to)2410-2421
Number of pages12
JournalJournal of Evolutionary Biology
Volume23
Issue number11
DOIs
Publication statusPublished - 01 Nov 2010
Externally publishedYes

Keywords

  • Comparative genomics
  • Duplication
  • Evolution
  • Fitness effects
  • Modelling
  • Protein family size
  • Response dynamics
  • Signalling network
  • Systems biology
  • Whole-genome duplication

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

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