Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

N. Irwin; P.L. McClean; F.P.M. O'Harte; V.A. Gault; Patrick Harriott; P.R. Flatt

doi:10.1007/s00125-007-0692-2

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

N. Irwin, P.L. McClean, F.P.M. O'Harte, V.A. Gault, Patrick Harriott, P.R. Flatt

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.

Original language	English
Pages (from-to)	1532-1540
Number of pages	9
Journal	Diabetologia
Volume	50
Issue number	7
DOIs	https://doi.org/10.1007/s00125-007-0692-2
Publication status	Published - Jul 2007

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Internal Medicine

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Irwin, N., McClean, P. L., O'Harte, F. P. M., Gault, V. A., Harriott, P., & Flatt, P. R. (2007). Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia, 50(7), 1532-1540. https://doi.org/10.1007/s00125-007-0692-2

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abstract = "Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.",

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Irwin, N, McClean, PL, O'Harte, FPM, Gault, VA, Harriott, P & Flatt, PR 2007, 'Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice', Diabetologia, vol. 50, no. 7, pp. 1532-1540. https://doi.org/10.1007/s00125-007-0692-2

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. / Irwin, N.; McClean, P.L.; O'Harte, F.P.M. et al.
In: Diabetologia, Vol. 50, No. 7, 07.2007, p. 1532-1540.

Research output: Contribution to journal › Article › peer-review

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AB - Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.

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Irwin N, McClean PL, O'Harte FPM, Gault VA, Harriott P, Flatt PR. Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia. 2007 Jul;50(7):1532-1540. doi: 10.1007/s00125-007-0692-2

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

Abstract

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