Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

N. Irwin, P.L. McClean, F.P.M. O'Harte, V.A. Gault, Patrick Harriott, P.R. Flatt

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Abstract

Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.
Original languageEnglish
Pages (from-to)1532-1540
Number of pages9
JournalDiabetologia
Volume50
Issue number7
DOIs
Publication statusPublished - Jul 2007

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Obesity
gastric inhibitory polypeptide receptor
pro-glucose-dependent insulinotropic polypeptide

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abstract = "Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.",
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Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. / Irwin, N.; McClean, P.L.; O'Harte, F.P.M.; Gault, V.A.; Harriott, Patrick; Flatt, P.R.

In: Diabetologia, Vol. 50, No. 7, 07.2007, p. 1532-1540.

Research output: Contribution to journalArticle

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AU - McClean, P.L.

AU - O'Harte, F.P.M.

AU - Gault, V.A.

AU - Harriott, Patrick

AU - Flatt, P.R.

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