Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

N. Irwin; P.L. McClean; F.P.M. O'Harte; V.A. Gault; Patrick Harriott; P.R. Flatt

doi:10.1007/s00125-007-0692-2

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

N. Irwin, P.L. McClean, F.P.M. O'Harte, V.A. Gault, Patrick Harriott, P.R. Flatt

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.

Original language	English
Pages (from-to)	1532-1540
Number of pages	9
Journal	Diabetologia
Volume	50
Issue number	7
DOIs	https://doi.org/10.1007/s00125-007-0692-2
Publication status	Published - Jul 2007

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00125-007-0692-2

Fingerprint

Dive into the research topics of 'Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice'. Together they form a unique fingerprint.

Cite this

Irwin, N., McClean, P. L., O'Harte, F. P. M., Gault, V. A., Harriott, P., & Flatt, P. R. (2007). Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia, 50(7), 1532-1540. https://doi.org/10.1007/s00125-007-0692-2

@article{6868fffa5d5a4d36ab75857b61b1ef74,

title = "Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice",

abstract = "Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.",

author = "N. Irwin and P.L. McClean and F.P.M. O'Harte and V.A. Gault and Patrick Harriott and P.R. Flatt",

year = "2007",

month = jul,

doi = "10.1007/s00125-007-0692-2",

language = "English",

volume = "50",

pages = "1532--1540",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "7",

}

Irwin, N, McClean, PL, O'Harte, FPM, Gault, VA, Harriott, P & Flatt, PR 2007, 'Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice', Diabetologia, vol. 50, no. 7, pp. 1532-1540. https://doi.org/10.1007/s00125-007-0692-2

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. / Irwin, N.; McClean, P.L.; O'Harte, F.P.M. et al.
In: Diabetologia, Vol. 50, No. 7, 07.2007, p. 1532-1540.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

AU - Irwin, N.

AU - McClean, P.L.

AU - O'Harte, F.P.M.

AU - Gault, V.A.

AU - Harriott, Patrick

AU - Flatt, P.R.

PY - 2007/7

Y1 - 2007/7

N2 - Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.

AB - Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes.

UR - https://www.scopus.com/pages/publications/34249941340

U2 - 10.1007/s00125-007-0692-2

DO - 10.1007/s00125-007-0692-2

M3 - Article

SN - 0012-186X

VL - 50

SP - 1532

EP - 1540

JO - Diabetologia

JF - Diabetologia

IS - 7

ER -

Irwin N, McClean PL, O'Harte FPM, Gault VA, Harriott P, Flatt PR. Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia. 2007 Jul;50(7):1532-1540. doi: 10.1007/s00125-007-0692-2

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this