Early X-irradiation of rats-4. Decrease in phosphorylation of low molecular weight proteins in the olfactory bulb accompanies the loss of GABAergic microneurons

Z. Oláh; I. Lengyel; N. Halász

doi:10.1016/0197-0186(90)90110-F

Early X-irradiation of rats-4. Decrease in phosphorylation of low molecular weight proteins in the olfactory bulb accompanies the loss of GABAergic microneurons

Z. Oláh^*, I. Lengyel, N. Halász

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

X-irradiation of neonatal rats by low, fragmented and repeated doses reduces or eliminates several phosphoproteins (16, 18 and 19 Da) in an extract of the olfactory bulb. This coincides with a dramatic reduction of the number of GABAergic granule cells. The phosphorylation of these proteins was specifically stimulated in control animals by Ca²⁺/calmodulin, but not by cyclic adenosine triphosphate. The reduced inhibitory function, observed previously in other "granuloprived" bulbs, might be the consequence of loss of those cells expressing these low molecular weight phosphoproteins. To assess the cellular changes caused by X-irradiation, low molecular weight phosphoproteins can serve as specific markers in the olfactory bulb.

Original language	English
Pages (from-to)	331-334
Number of pages	4
Journal	Neurochemistry International
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/0197-0186(90)90110-F
Publication status	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Cellular and Molecular Neuroscience

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abstract = "X-irradiation of neonatal rats by low, fragmented and repeated doses reduces or eliminates several phosphoproteins (16, 18 and 19 Da) in an extract of the olfactory bulb. This coincides with a dramatic reduction of the number of GABAergic granule cells. The phosphorylation of these proteins was specifically stimulated in control animals by Ca2+/calmodulin, but not by cyclic adenosine triphosphate. The reduced inhibitory function, observed previously in other {"}granuloprived{"} bulbs, might be the consequence of loss of those cells expressing these low molecular weight phosphoproteins. To assess the cellular changes caused by X-irradiation, low molecular weight phosphoproteins can serve as specific markers in the olfactory bulb.",

author = "Z. Ol{\'a}h and I. Lengyel and N. Hal{\'a}sz",

year = "1990",

doi = "10.1016/0197-0186(90)90110-F",

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T1 - Early X-irradiation of rats-4. Decrease in phosphorylation of low molecular weight proteins in the olfactory bulb accompanies the loss of GABAergic microneurons

AU - Oláh, Z.

AU - Lengyel, I.

AU - Halász, N.

PY - 1990

Y1 - 1990

N2 - X-irradiation of neonatal rats by low, fragmented and repeated doses reduces or eliminates several phosphoproteins (16, 18 and 19 Da) in an extract of the olfactory bulb. This coincides with a dramatic reduction of the number of GABAergic granule cells. The phosphorylation of these proteins was specifically stimulated in control animals by Ca2+/calmodulin, but not by cyclic adenosine triphosphate. The reduced inhibitory function, observed previously in other "granuloprived" bulbs, might be the consequence of loss of those cells expressing these low molecular weight phosphoproteins. To assess the cellular changes caused by X-irradiation, low molecular weight phosphoproteins can serve as specific markers in the olfactory bulb.

AB - X-irradiation of neonatal rats by low, fragmented and repeated doses reduces or eliminates several phosphoproteins (16, 18 and 19 Da) in an extract of the olfactory bulb. This coincides with a dramatic reduction of the number of GABAergic granule cells. The phosphorylation of these proteins was specifically stimulated in control animals by Ca2+/calmodulin, but not by cyclic adenosine triphosphate. The reduced inhibitory function, observed previously in other "granuloprived" bulbs, might be the consequence of loss of those cells expressing these low molecular weight phosphoproteins. To assess the cellular changes caused by X-irradiation, low molecular weight phosphoproteins can serve as specific markers in the olfactory bulb.

U2 - 10.1016/0197-0186(90)90110-F

DO - 10.1016/0197-0186(90)90110-F

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JO - Neurochemistry International

JF - Neurochemistry International

IS - 3

ER -

Early X-irradiation of rats-4. Decrease in phosphorylation of low molecular weight proteins in the olfactory bulb accompanies the loss of GABAergic microneurons

Abstract

ASJC Scopus subject areas

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