Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat

N.L. Alderson, M.E. Chachich, Kerry Frizzell, Paul Canning, T.O. Metz, A.S. Januszewski, Omar Youssef, Alan Stitt, John Baynes, Suzanne Thorpe

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

Aims/hypothesis. This study was designed to determine whether inhibition of formation of AGE and advanced lipoxidation end-products (ALE) is a mechanism of action common to a diverse group of therapeutic agents that limit the progress of diabetic nephropathy. We compared the effects of the ACE inhibitor enalapril, the antioxidant vitamin E, the thiol compound lipoic acid, and the AGE/ALE inhibitor pyridoxamine on the formation of AGE/ALE and protection against nephropathy in streptozotocin diabetic rats.
Original languageEnglish
Pages (from-to)1385-1395
Number of pages11
JournalDiabetologia
Volume47
Issue number8
DOIs
Publication statusPublished - Aug 2004

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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