Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat

N.L. Alderson; M.E. Chachich; Kerry Frizzell; Paul Canning; T.O. Metz; A.S. Januszewski; Omar Youssef; Alan Stitt; John Baynes; Suzanne Thorpe

doi:10.1007/s00125-004-1474-8

Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat

N.L. Alderson
, M.E. Chachich
, Kerry Frizzell
, Paul Canning
, T.O. Metz
, A.S. Januszewski
, Omar Youssef
, Alan Stitt
, John Baynes
, Suzanne Thorpe

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

Aims/hypothesis. This study was designed to determine whether inhibition of formation of AGE and advanced lipoxidation end-products (ALE) is a mechanism of action common to a diverse group of therapeutic agents that limit the progress of diabetic nephropathy. We compared the effects of the ACE inhibitor enalapril, the antioxidant vitamin E, the thiol compound lipoic acid, and the AGE/ALE inhibitor pyridoxamine on the formation of AGE/ALE and protection against nephropathy in streptozotocin diabetic rats.

Original language	English
Pages (from-to)	1385-1395
Number of pages	11
Journal	Diabetologia
Volume	47
Issue number	8
DOIs	https://doi.org/10.1007/s00125-004-1474-8
Publication status	Published - Aug 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Internal Medicine

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10.1007/s00125-004-1474-8

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Alderson, N. L., Chachich, M. E., Frizzell, K., Canning, P., Metz, T. O., Januszewski, A. S., Youssef, O., Stitt, A., Baynes, J., & Thorpe, S. (2004). Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat. Diabetologia, 47(8), 1385-1395. https://doi.org/10.1007/s00125-004-1474-8

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author = "N.L. Alderson and M.E. Chachich and Kerry Frizzell and Paul Canning and T.O. Metz and A.S. Januszewski and Omar Youssef and Alan Stitt and John Baynes and Suzanne Thorpe",

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T1 - Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat

AU - Alderson, N.L.

AU - Chachich, M.E.

AU - Frizzell, Kerry

AU - Canning, Paul

AU - Metz, T.O.

AU - Januszewski, A.S.

AU - Youssef, Omar

AU - Stitt, Alan

AU - Baynes, John

AU - Thorpe, Suzanne

PY - 2004/8

Y1 - 2004/8

N2 - Aims/hypothesis. This study was designed to determine whether inhibition of formation of AGE and advanced lipoxidation end-products (ALE) is a mechanism of action common to a diverse group of therapeutic agents that limit the progress of diabetic nephropathy. We compared the effects of the ACE inhibitor enalapril, the antioxidant vitamin E, the thiol compound lipoic acid, and the AGE/ALE inhibitor pyridoxamine on the formation of AGE/ALE and protection against nephropathy in streptozotocin diabetic rats.

AB - Aims/hypothesis. This study was designed to determine whether inhibition of formation of AGE and advanced lipoxidation end-products (ALE) is a mechanism of action common to a diverse group of therapeutic agents that limit the progress of diabetic nephropathy. We compared the effects of the ACE inhibitor enalapril, the antioxidant vitamin E, the thiol compound lipoic acid, and the AGE/ALE inhibitor pyridoxamine on the formation of AGE/ALE and protection against nephropathy in streptozotocin diabetic rats.

U2 - 10.1007/s00125-004-1474-8

DO - 10.1007/s00125-004-1474-8

M3 - Article

SN - 0012-186X

VL - 47

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JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat

Abstract

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