Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease

Cathryn Patterson, Stephen Todd, Peter Passmore

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Factors that influence response to drug treatment are of increasing importance. We report an analysis of genetic factors affecting response to cholinesterase inhibitor therapy in 165 subjects with Alzheimer's disease (AD). The presence of apolipoprotein E e4 (APOE e4) allele was associated with early and late cognitive response to cholinesterase inhibitor treatment in mild AD (Mini-Mental State Examination (MMSE) greater than or equal to21) (P
Original languageEnglish
Pages (from-to)444-450
Number of pages7
JournalPharmacogenomics
Volume11
Issue number6
DOIs
Publication statusPublished - Dec 2011

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Genetics

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