Effect of atorvastatin on circulating hsCRP concentrations: A sub-study of the Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration (ACTFAST) study

G.F. Gensini, A.M. Gori, B. Dilaghi, C. Rostagno, Allan Gaw, L.M. Blanco-Colio, E. De Teresa, J. Egido, C. Farsang, L.A. Leiter, P. Martineau, A. Nozza, A. Langer

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11 Citations (Scopus)

Abstract

Background: Elevated C-reactive protein (CRP) concentration is a risk factor for cardiovascular events that may add prognostic information. Statin treatment is associated with significant reductions in CRP concentrations, which appear to be unrelated to the magnitude of LDL-cholesterol reduction. We investigated the effect of atorvastatin, across its dose range, on high sensitivity (hs)CRP in subjects at high cardiovascular risk. Methods: ACTFAST was a 12 week, prospective, multicenter, open-label trial in which high-risk subjects were assigned a starting dose of atorvastatin (10, 20, 40 or 80 mg/d) based on LDL-C and status of statin use at screening (1345 statin-free [ SF] and 772 previously statin-treated [ST]). Results: At baseline, ST subjects had significantly lower hsCRP levels than SF subjects (ST group 2.31, 95% CI 2.15, 2.48 mg/L vs. SF group 3.16, 95% CI 2.98, 3.34 mg/L, p
Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalInternational Journal of Cardiology
Volume142
Issue number3
DOIs
Publication statusPublished - 23 Jul 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Gensini, G. F., Gori, A. M., Dilaghi, B., Rostagno, C., Gaw, A., Blanco-Colio, L. M., De Teresa, E., Egido, J., Farsang, C., Leiter, L. A., Martineau, P., Nozza, A., & Langer, A. (2010). Effect of atorvastatin on circulating hsCRP concentrations: A sub-study of the Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration (ACTFAST) study. International Journal of Cardiology, 142(3), 257-264. https://doi.org/10.1016/j.ijcard.2008.12.213