Effect of carrier type and surfactant concentration on the silymarin release

Valentyn Mohylyuk, Thomas Pauly, Oleksandr Dobrovolnyi, Nathan Scott, David Jones, Gavin Andrews

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Abstract

Silymarin, being the flavonoid complex isolated from Silybum marianum fruits is widely used and has new prospects to be used in medicine. Silybin (also known as silibinin) is main component of silymarin with attributed therapeutically properties. Silymarin behave as weak acid, can be considered as a Class II drug and has slow dissolution kinetics at pH 7.4 and low bioavailability (1). The inhibition of gut wall efflux with additional formulation components, the bypassing the gut wall efflux by lymphatic transport and the increasing intestinal flux by increasing of drug concentration in the place of absorption are well-known strategies for the improvement of bioavailability. The main objective of this study was to justify the chosen formulation strategy and to investigate the drug release of silymarin as function of carrier type (Avicel® PH-102 vs. Syloid® XDP 3150) and surface-active substance (Tween® 80) concentration.
Original languageEnglish
Publication statusPublished - 11 May 2021
Event12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (delayed due to COVID19) -
Duration: 11 May 202114 May 2021

Conference

Conference12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (delayed due to COVID19)
Period11/05/202114/05/2021

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