Effect of diluent types and soluble diluents particle size on the dissolution profile of trimetazidine dihydrochloride and caffeine from kollidon SR matrix tablets

Valentyn Mohylyuk*, Lena Davtian

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Effect of different diluents types on the dissolution profile of trimetazidine dihydrochloride and caffeine from Kollidon SR matrix tablets was investigated using microcrystalline cellulose (Avicel PH-101), calcium hydrogen phosphate dihydrate (Emcompress) and sorbitol (Neosorb P100T). The decreasing of mentioned diluents possibility to slow down of model substances dissolution kinetics (at pH 6.8) had follow sequence: Avicel PH-101 >Emcompress>Neosorb P100T.Effect of soluble diluents particle size on dissolution profile of trimetazidine dihydrochloride and caffeine from Kollidon SR matrix tablets was investigated using sorbitol (Neosorb P100T, Neosorb P60 W and Neosorb P30/60) and lactose monohydrate (Sorbolac 400, Granulac 200 and Capsulac 60). The particle size increasing of lactose monohydrate from 11 to 251 μm and sorbitol from 110 to 513 μm decreased dissolution kinetics of model substances from Kollidon SR matrix tablets.

Original languageEnglish
Pages (from-to)147-155
JournalInternational Journal of PharmTech Research
Volume8
Issue number6
Publication statusPublished - 01 Nov 2015
Externally publishedYes

Keywords

  • Caffeine
  • Diluent
  • Kollidon SR
  • Matrix tablets
  • Particle size
  • Trimetazidine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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