Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial

F.R. Baldrick, Stuart Elborn, Jayne Woodside, K. Treacy, J. Bradley, Christopher Patterson, Bettina Schock, Madeleine Ennis, Ian Young, Michelle McKinley

Research output: Contribution to journalArticle

32 Citations (Scopus)
22 Downloads (Pure)

Abstract

Epidemiological evidence supports a positive relationship between fruit and vegetable (FV) intake, lung function and chronic obstructive pulmonary disease (COPD). Increasing FV intake may attenuate the oxidative stress and inflammation associated with COPD.

An exploratory randomised controlled trial to examine the effect of increased consumption of FV on oxidative stress and inflammation in moderate-to-severe COPD was conducted. 81 symptomatically stable patients with a habitually low FV intake (two or fewer portions of FV per day) were randomised to the intervention group (five or more portions of FV per day) or the control group (two or fewer portions of FV per day). Each participant received self-selected weekly home deliveries of FV for 12 weeks.

75 participants completed the intervention. There was a significant between-group change in self-reported FV intake and biomarkers of FV intake (zeaxanthin (p=0.034) and ß-cryptoxanthin (p=0.015)), indicating good compliance; post-intervention intakes in intervention and control groups were 6.1 and 1.9 portions of FV per day, respectively. There were no significant changes in biomarkers of airway inflammation (interleukin-8 and myeloperoxidase) and systemic inflammation (C-reactive protein) or airway and systemic oxidative stress (8-isoprostane).

This exploratory study demonstrated that patients with moderate-to-severe COPD were able to comply with an intervention to increase FV intake; however, this had no significant effect on airway or systemic oxidative stress and inflammation.
Original languageEnglish
Pages (from-to)1377-1384
Number of pages8
JournalEuropean Respiratory Journal
VolumeIn press
Issue number6
Early online date16 Nov 2011
DOIs
Publication statusPublished - 01 Dec 2011

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial'. Together they form a unique fingerprint.

Cite this