Effect of Impeller Design on Homogeneity, Size and Strength of Pharmaceutical Granules produced by High Shear Wet Granulation

Zakaria Mirza, JiangTao Liu, Yoann Glocheux, Ahmad B. Albadarin, Gavin M. Walker, Chirangano Mangwandi*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)
792 Downloads (Pure)

Abstract

Small mixer impeller design is not tailored for granulation because impellers are intended for a wide range of processes. The aim of this research was to evaluate the performances of several impellers to provide guidance on the selection and design for the purposes of granulation. Lactose granules were produced using wet granulation with water as a binder. A Kenwood KM070 mixer was used as a standard apparatus and five impeller designs with different shapes and surface areas were used. The efficacy of granulate formation was measured by adding an optically sensitive tracer to determine variations in active ingredient content across random samples of granules from the same size classes. It was found that impeller design influenced the homogeneity of the granules and therefore can affect final product performance. The variation in active ingredient content across granules of differing size was also investigated. The results show that small granules were more potent than larger granules.
Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalParticuology
Volume23
Early online date20 Apr 2015
DOIs
Publication statusPublished - Dec 2015

Keywords

  • Granulation
  • impeller design
  • homogeneity
  • granule strength
  • high shear granulation

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