Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial

Debra A Schaumberg, Robert J Glynn, Alicia J Jenkins, Timothy J Lyons, Nader Rifai, JoAnn E Manson, Paul M Ridker, David M Nathan

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Abstract

Type 1 diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) that is not fully explained by conventional risk factors. The Diabetes Control and Complications Trial (DCCT) showed that intensive diabetes therapy reduced levels of LDL cholesterol and triglycerides but increased the risk of major weight gain, which might adversely affect CVD risk. The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD.
Original languageEnglish
Pages (from-to)2446-53
Number of pages8
JournalCirculation
Volume111
Issue number19
DOIs
Publication statusPublished - 17 May 2005

Keywords

  • Adolescent
  • Adult
  • Biological Markers
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 1
  • Diabetic Angiopathies
  • Female
  • Humans
  • Hypoglycemic Agents
  • Inflammation
  • Insulin
  • Male
  • Risk Factors
  • Weight Gain

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    Schaumberg, D. A., Glynn, R. J., Jenkins, A. J., Lyons, T. J., Rifai, N., Manson, J. E., Ridker, P. M., & Nathan, D. M. (2005). Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial. Circulation, 111(19), 2446-53. https://doi.org/10.1161/01.CIR.0000165064.31505.3B