Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial

Debra A Schaumberg; Robert J Glynn; Alicia J Jenkins; Timothy J Lyons; Nader Rifai; JoAnn E Manson; Paul M Ridker; David M Nathan

doi:10.1161/01.CIR.0000165064.31505.3B

Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial

Debra A Schaumberg
, Robert J Glynn
, Alicia J Jenkins
, Timothy J Lyons
, Nader Rifai
, JoAnn E Manson
, Paul M Ridker
, David M Nathan

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

104 Citations (Scopus)

Abstract

Type 1 diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) that is not fully explained by conventional risk factors. The Diabetes Control and Complications Trial (DCCT) showed that intensive diabetes therapy reduced levels of LDL cholesterol and triglycerides but increased the risk of major weight gain, which might adversely affect CVD risk. The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD.

Original language	English
Pages (from-to)	2446-53
Number of pages	8
Journal	Circulation
Volume	111
Issue number	19
DOIs	https://doi.org/10.1161/01.CIR.0000165064.31505.3B
Publication status	Published - 17 May 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adolescent
Adult
Biological Markers
Cardiovascular Diseases
Diabetes Mellitus, Type 1
Diabetic Angiopathies
Female
Humans
Hypoglycemic Agents
Inflammation
Insulin
Male
Risk Factors
Weight Gain

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10.1161/01.CIR.0000165064.31505.3B

Cite this

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title = "Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial",

abstract = "Type 1 diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) that is not fully explained by conventional risk factors. The Diabetes Control and Complications Trial (DCCT) showed that intensive diabetes therapy reduced levels of LDL cholesterol and triglycerides but increased the risk of major weight gain, which might adversely affect CVD risk. The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD.",

keywords = "Adolescent, Adult, Biological Markers, Cardiovascular Diseases, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Female, Humans, Hypoglycemic Agents, Inflammation, Insulin, Male, Risk Factors, Weight Gain",

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year = "2005",

month = may,

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doi = "10.1161/01.CIR.0000165064.31505.3B",

language = "English",

volume = "111",

pages = "2446--53",

journal = "Circulation",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial

AU - Schaumberg, Debra A

AU - Glynn, Robert J

AU - Jenkins, Alicia J

AU - Lyons, Timothy J

AU - Rifai, Nader

AU - Manson, JoAnn E

AU - Ridker, Paul M

AU - Nathan, David M

PY - 2005/5/17

Y1 - 2005/5/17

N2 - Type 1 diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) that is not fully explained by conventional risk factors. The Diabetes Control and Complications Trial (DCCT) showed that intensive diabetes therapy reduced levels of LDL cholesterol and triglycerides but increased the risk of major weight gain, which might adversely affect CVD risk. The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD.

AB - Type 1 diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) that is not fully explained by conventional risk factors. The Diabetes Control and Complications Trial (DCCT) showed that intensive diabetes therapy reduced levels of LDL cholesterol and triglycerides but increased the risk of major weight gain, which might adversely affect CVD risk. The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD.

KW - Adolescent

KW - Adult

KW - Biological Markers

KW - Cardiovascular Diseases

KW - Diabetes Mellitus, Type 1

KW - Diabetic Angiopathies

KW - Female

KW - Humans

KW - Hypoglycemic Agents

KW - Inflammation

KW - Insulin

KW - Male

KW - Risk Factors

KW - Weight Gain

U2 - 10.1161/01.CIR.0000165064.31505.3B

DO - 10.1161/01.CIR.0000165064.31505.3B

M3 - Article

C2 - 15867184

SN - 0009-7322

VL - 111

SP - 2446

EP - 2453

JO - Circulation

JF - Circulation

IS - 19

ER -

Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial

Abstract

UN SDGs

Keywords

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