Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers

A Gostner, M Blaut, V Schäffer, G Kozianowski, S Theis, M Klingeberg, Y Dombrowski, D Martin, S Ehrhardt, D Taras, A Schwiertz, B Kleessen, H Lührs, J Schauber, D Dorbath, T Menzel, W Scheppach

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68 Citations (Scopus)


Due to its low digestibility in the small intestine, a major fraction of the polyol isomalt reaches the colon. However, little is known about effects on the intestinal microflora. During two 4-week periods in a double-blind, placebo-controlled, cross-over design, nineteen healthy volunteers consumed a controlled basal diet enriched with either 30 g isomalt or 30 g sucrose daily. Stools were collected at the end of each test phase and various microbiological and luminal markers were analysed. Fermentation characteristics of isomalt were also investigated in vitro. Microbiological analyses of faecal samples indicated a shift of the gut flora towards an increase of bifidobacteria following consumption of the isomalt diet compared with the sucrose diet (P
Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalThe British journal of nutrition
Issue number1
Publication statusPublished - Jan 2006


  • Adult
  • Ammonia
  • Bifidobacterium
  • Bile Acids and Salts
  • Colon
  • Colony Count, Microbial
  • Cresols
  • Dietary Carbohydrates
  • Disaccharides
  • Fats
  • Fatty Acids, Volatile
  • Feces
  • Female
  • Fermentation
  • Humans
  • Hydrogen-Ion Concentration
  • In Situ Hybridization, Fluorescence
  • Lactates
  • Male
  • Middle Aged
  • Nitrogen
  • Phenol
  • Polyamines
  • Sterols
  • Sugar Alcohols
  • Sweetening Agents


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