Effect of osteoporosis on bone mineral density and fracture repair in a rat femoral fracture model

Roseleen McCann, Gary Colleary, Carolyn Geddis, Susan Clarke, Grant Jordan, Glenn Dickson, D Marsh

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


Osteoporosis (OP) is one of the most prevalent bone diseases worldwide with bone fracture the major clinical consequence. The effect of OP on fracture repair is disputed and although it might be expected for fracture repair to be delayed in osteoporotic individuals, a definitive answer to this question still eludes us. The aim of this study was to clarify the effect of osteoporosis in a rodent fracture model. OP was induced in 3-month-old rats (n = 53) by ovariectomy (OVX) followed by an externally fixated, mid-diaphyseal femoral osteotomy at 6 months (OVX group). A further 40 animals underwent a fracture at 6 months (control group). Animals were sacrificed at 1, 2, 4, 6, and 8 weeks postfracture with outcome measures of histology, biomechanical strength testing, pQCT, relative BMD, and motion detection. OVX animals had significantly lower BMD, slower fracture repair (histologically), reduced stiffness in the fractured femora (8 weeks) and strength in the contralateral femora (6 and 8 weeks), increased body weight, and decreased motion. This study has demonstrated that OVX is associated with decrease in BMD (particularly in trabecular bone) and a reduction in the mechanical properties of intact bone and healing fractures. The histological, biomechanical, and radiological measures of union suggest that OVX delayed fracture healing. (C) 2007 Orthopaedic Research Society. Published by Wiley Periodicals.
Original languageEnglish
Pages (from-to)384-393
Number of pages10
JournalJournal of orthopaedic research : official publication of the Orthopaedic Research Society
Issue number3
Publication statusPublished - Mar 2008

ASJC Scopus subject areas

  • Medicine(all)
  • Orthopedics and Sports Medicine

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