Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study

Hans-Christoph Diener; Ralph L Sacco; Salim Yusuf; Daniel Cotton; Stephanie Ounpuu; William A Lawton; Yuko Palesch; Reneé H Martin; Gregory W Albers; Philip Bath; Natan Bornstein; Bernard P L Chan; Sien-Tsong Chen; Luis Cunha; Björn Dahlöf; Jacques De Keyser; Geoffrey A Donnan; Conrado Estol; Philip Gorelick; Vivian Gu; Karin Hermansson; Lutz Hilbrich; Markku Kaste; Chuanzhen Lu; Thomas Machnig; Prem Pais; Robin Roberts; Veronika Skvortsova; Philip Teal; Danilo Toni; Cam VanderMaelen; Thor Voigt; Michael Weber; Byung-Woo Yoon; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group; Peter Passmore

doi:10.1016/S1474-4422(08)70198-4

Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study

Hans-Christoph Diener, Ralph L Sacco, Salim Yusuf, Daniel Cotton, Stephanie Ounpuu, William A Lawton, Yuko Palesch, Reneé H Martin, Gregory W Albers, Philip Bath, Natan Bornstein, Bernard P L Chan, Sien-Tsong Chen, Luis Cunha, Björn Dahlöf, Jacques De Keyser, Geoffrey A Donnan, Conrado Estol, Philip Gorelick, Vivian GuKarin Hermansson, Lutz Hilbrich, Markku Kaste, Chuanzhen Lu, Thomas Machnig, Prem Pais, Robin Roberts, Veronika Skvortsova, Philip Teal, Danilo Toni, Cam VanderMaelen, Thor Voigt, Michael Weber, Byung-Woo Yoon, Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group, Peter Passmore

Research output: Contribution to journal › Article › peer-review

234 Citations (Scopus)

Abstract

The treatment of ischaemic stroke with neuroprotective drugs has been unsuccessful, and whether these compounds can be used to reduce disability after recurrent stroke is unknown. The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial.

Original language	English
Pages (from-to)	875-84
Number of pages	10
Journal	Lancet Neurology
Volume	7
Issue number	10
DOIs	https://doi.org/10.1016/S1474-4422(08)70198-4
Publication status	Published - Oct 2008

ASJC Scopus subject areas

Clinical Neurology

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Diener, H-C., Sacco, R. L., Yusuf, S., Cotton, D., Ounpuu, S., Lawton, W. A., Palesch, Y., Martin, R. H., Albers, G. W., Bath, P., Bornstein, N., Chan, B. P. L., Chen, S-T., Cunha, L., Dahlöf, B., De Keyser, J., Donnan, G. A., Estol, C., Gorelick, P., ... Passmore, P. (2008). Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurology, 7(10), 875-84. https://doi.org/10.1016/S1474-4422(08)70198-4

Diener, Hans-Christoph ; Sacco, Ralph L ; Yusuf, Salim ; Cotton, Daniel ; Ounpuu, Stephanie ; Lawton, William A ; Palesch, Yuko ; Martin, Reneé H ; Albers, Gregory W ; Bath, Philip ; Bornstein, Natan ; Chan, Bernard P L ; Chen, Sien-Tsong ; Cunha, Luis ; Dahlöf, Björn ; De Keyser, Jacques ; Donnan, Geoffrey A ; Estol, Conrado ; Gorelick, Philip ; Gu, Vivian ; Hermansson, Karin ; Hilbrich, Lutz ; Kaste, Markku ; Lu, Chuanzhen ; Machnig, Thomas ; Pais, Prem ; Roberts, Robin ; Skvortsova, Veronika ; Teal, Philip ; Toni, Danilo ; VanderMaelen, Cam ; Voigt, Thor ; Weber, Michael ; Yoon, Byung-Woo ; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group ; Passmore, Peter. / Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial : a double-blind, active and placebo-controlled study. In: Lancet Neurology. 2008 ; Vol. 7, No. 10. pp. 875-84.

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title = "Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study",

abstract = "The treatment of ischaemic stroke with neuroprotective drugs has been unsuccessful, and whether these compounds can be used to reduce disability after recurrent stroke is unknown. The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial.",

author = "Hans-Christoph Diener and Sacco, {Ralph L} and Salim Yusuf and Daniel Cotton and Stephanie Ounpuu and Lawton, {William A} and Yuko Palesch and Martin, {Rene{\'e} H} and Albers, {Gregory W} and Philip Bath and Natan Bornstein and Chan, {Bernard P L} and Sien-Tsong Chen and Luis Cunha and Bj{\"o}rn Dahl{\"o}f and {De Keyser}, Jacques and Donnan, {Geoffrey A} and Conrado Estol and Philip Gorelick and Vivian Gu and Karin Hermansson and Lutz Hilbrich and Markku Kaste and Chuanzhen Lu and Thomas Machnig and Prem Pais and Robin Roberts and Veronika Skvortsova and Philip Teal and Danilo Toni and Cam VanderMaelen and Thor Voigt and Michael Weber and Byung-Woo Yoon and {Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group} and Peter Passmore",

year = "2008",

month = oct,

doi = "10.1016/S1474-4422(08)70198-4",

language = "English",

volume = "7",

pages = "875--84",

journal = "Lancet Neurology",

issn = "1474-4422",

publisher = "Lancet Publishing Group",

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Diener, H-C, Sacco, RL, Yusuf, S, Cotton, D, Ounpuu, S, Lawton, WA, Palesch, Y, Martin, RH, Albers, GW, Bath, P, Bornstein, N, Chan, BPL, Chen, S-T, Cunha, L, Dahlöf, B, De Keyser, J, Donnan, GA, Estol, C, Gorelick, P, Gu, V, Hermansson, K, Hilbrich, L, Kaste, M, Lu, C, Machnig, T, Pais, P, Roberts, R, Skvortsova, V, Teal, P, Toni, D, VanderMaelen, C, Voigt, T, Weber, M, Yoon, B-W, Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group & Passmore, P 2008, 'Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study', Lancet Neurology, vol. 7, no. 10, pp. 875-84. https://doi.org/10.1016/S1474-4422(08)70198-4

Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial : a double-blind, active and placebo-controlled study. / Diener, Hans-Christoph; Sacco, Ralph L; Yusuf, Salim; Cotton, Daniel; Ounpuu, Stephanie; Lawton, William A; Palesch, Yuko; Martin, Reneé H; Albers, Gregory W; Bath, Philip; Bornstein, Natan; Chan, Bernard P L; Chen, Sien-Tsong; Cunha, Luis; Dahlöf, Björn; De Keyser, Jacques; Donnan, Geoffrey A; Estol, Conrado; Gorelick, Philip; Gu, Vivian; Hermansson, Karin; Hilbrich, Lutz; Kaste, Markku; Lu, Chuanzhen; Machnig, Thomas; Pais, Prem; Roberts, Robin; Skvortsova, Veronika; Teal, Philip; Toni, Danilo; VanderMaelen, Cam; Voigt, Thor; Weber, Michael; Yoon, Byung-Woo; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group ; Passmore, Peter.

In: Lancet Neurology, Vol. 7, No. 10, 10.2008, p. 875-84.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial

T2 - a double-blind, active and placebo-controlled study

AU - Diener, Hans-Christoph

AU - Sacco, Ralph L

AU - Yusuf, Salim

AU - Cotton, Daniel

AU - Ounpuu, Stephanie

AU - Lawton, William A

AU - Palesch, Yuko

AU - Martin, Reneé H

AU - Albers, Gregory W

AU - Bath, Philip

AU - Bornstein, Natan

AU - Chan, Bernard P L

AU - Chen, Sien-Tsong

AU - Cunha, Luis

AU - Dahlöf, Björn

AU - De Keyser, Jacques

AU - Donnan, Geoffrey A

AU - Estol, Conrado

AU - Gorelick, Philip

AU - Gu, Vivian

AU - Hermansson, Karin

AU - Hilbrich, Lutz

AU - Kaste, Markku

AU - Lu, Chuanzhen

AU - Machnig, Thomas

AU - Pais, Prem

AU - Roberts, Robin

AU - Skvortsova, Veronika

AU - Teal, Philip

AU - Toni, Danilo

AU - VanderMaelen, Cam

AU - Voigt, Thor

AU - Weber, Michael

AU - Yoon, Byung-Woo

AU - Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group

AU - Passmore, Peter

PY - 2008/10

Y1 - 2008/10

N2 - The treatment of ischaemic stroke with neuroprotective drugs has been unsuccessful, and whether these compounds can be used to reduce disability after recurrent stroke is unknown. The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial.

AB - The treatment of ischaemic stroke with neuroprotective drugs has been unsuccessful, and whether these compounds can be used to reduce disability after recurrent stroke is unknown. The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial.

U2 - 10.1016/S1474-4422(08)70198-4

DO - 10.1016/S1474-4422(08)70198-4

M3 - Article

C2 - 18757238

VL - 7

SP - 875

EP - 884

JO - Lancet Neurology

JF - Lancet Neurology

SN - 1474-4422

IS - 10

ER -

Diener H-C, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA et al. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurology. 2008 Oct;7(10):875-84. https://doi.org/10.1016/S1474-4422(08)70198-4