Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections

Suelen H Qassim; Hiam Chemaitelly; Houssein H Ayoub; Sawsan AlMukdad; Patrick Tang; Mohammad R Hasan; Hadi M Yassine; Hebah A Al-Khatib; Maria K Smatti; Hanan F Abdul-Rahim; Gheyath K Nasrallah; Mohamed Ghaith Al-Kuwari; Abdullatif Al-Khal; Peter Coyle; Anvar Hassan Kaleeckal; Riyazuddin Mohammad Shaik; Ali Nizar Latif; Einas Al-Kuwari; Andrew Jeremijenko; Adeel A Butt; Roberto Bertollini; Hamad Eid Al-Romaihi; Mohamed H Al-Thani; Laith J Abu-Raddad

doi:10.1093/jtm/taac068

Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections

Suelen H Qassim, Hiam Chemaitelly, Houssein H Ayoub, Sawsan AlMukdad, Patrick Tang, Mohammad R Hasan, Hadi M Yassine, Hebah A Al-Khatib, Maria K Smatti, Hanan F Abdul-Rahim, Gheyath K Nasrallah, Mohamed Ghaith Al-Kuwari, Abdullatif Al-Khal, Peter Coyle, Anvar Hassan Kaleeckal, Riyazuddin Mohammad Shaik, Ali Nizar Latif, Einas Al-Kuwari, Andrew Jeremijenko, Adeel A ButtRoberto Bertollini, Hamad Eid Al-Romaihi, Mohamed H Al-Thani, Laith J Abu-Raddad

Wellcome Wolfson Institute for Experimental Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Compared to BA.1, BA.2 was associated with lower RT-qPCR cycle threshold (Ct) value—3.53 fewer cycles (95% CI: 3.46–3.60), signifying higher infectiousness. This may reflect higher viral load and/or longer duration of infection for BA.2. Natural immunity from previous infection and booster vaccination were associated with less infectious breakthrough infections.

Original language	English
Journal	Journal of Travel Medicine
Early online date	27 May 2022
DOIs	https://doi.org/10.1093/jtm/taac068
Publication status	Early online date - 27 May 2022

Keywords

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jtm/taac068Licence: CC BY

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Qassim, S. H., Chemaitelly, H., Ayoub, H. H., AlMukdad, S., Tang, P., Hasan, M. R., Yassine, H. M., Al-Khatib, H. A., Smatti, M. K., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., Al-Khal, A., Coyle, P., Kaleeckal, A. H., Shaik, R. M., Latif, A. N., Al-Kuwari, E., Jeremijenko, A., ... Abu-Raddad, L. J. (2022). Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections. Journal of Travel Medicine. https://doi.org/10.1093/jtm/taac068

Qassim, Suelen H ; Chemaitelly, Hiam ; Ayoub, Houssein H ; AlMukdad, Sawsan ; Tang, Patrick ; Hasan, Mohammad R ; Yassine, Hadi M ; Al-Khatib, Hebah A ; Smatti, Maria K ; Abdul-Rahim, Hanan F ; Nasrallah, Gheyath K ; Al-Kuwari, Mohamed Ghaith ; Al-Khal, Abdullatif ; Coyle, Peter ; Kaleeckal, Anvar Hassan ; Shaik, Riyazuddin Mohammad ; Latif, Ali Nizar ; Al-Kuwari, Einas ; Jeremijenko, Andrew ; Butt, Adeel A ; Bertollini, Roberto ; Al-Romaihi, Hamad Eid ; Al-Thani, Mohamed H ; Abu-Raddad, Laith J. / Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections. In: Journal of Travel Medicine. 2022.

@article{591f50ed8c6241b0980ea83d0b76b201,

title = "Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections",

abstract = "Compared to BA.1, BA.2 was associated with lower RT-qPCR cycle threshold (Ct) value—3.53 fewer cycles (95% CI: 3.46–3.60), signifying higher infectiousness. This may reflect higher viral load and/or longer duration of infection for BA.2. Natural immunity from previous infection and booster vaccination were associated with less infectious breakthrough infections.",

keywords = "General Medicine",

author = "Qassim, {Suelen H} and Hiam Chemaitelly and Ayoub, {Houssein H} and Sawsan AlMukdad and Patrick Tang and Hasan, {Mohammad R} and Yassine, {Hadi M} and Al-Khatib, {Hebah A} and Smatti, {Maria K} and Abdul-Rahim, {Hanan F} and Nasrallah, {Gheyath K} and Al-Kuwari, {Mohamed Ghaith} and Abdullatif Al-Khal and Peter Coyle and Kaleeckal, {Anvar Hassan} and Shaik, {Riyazuddin Mohammad} and Latif, {Ali Nizar} and Einas Al-Kuwari and Andrew Jeremijenko and Butt, {Adeel A} and Roberto Bertollini and Al-Romaihi, {Hamad Eid} and Al-Thani, {Mohamed H} and Abu-Raddad, {Laith J}",

year = "2022",

month = may,

day = "27",

doi = "10.1093/jtm/taac068",

language = "English",

journal = "Journal of Travel Medicine",

issn = "1195-1982",

publisher = "Wiley-Blackwell",

}

Qassim, SH, Chemaitelly, H, Ayoub, HH, AlMukdad, S, Tang, P, Hasan, MR, Yassine, HM, Al-Khatib, HA, Smatti, MK, Abdul-Rahim, HF, Nasrallah, GK, Al-Kuwari, MG, Al-Khal, A, Coyle, P, Kaleeckal, AH, Shaik, RM, Latif, AN, Al-Kuwari, E, Jeremijenko, A, Butt, AA, Bertollini, R, Al-Romaihi, HE, Al-Thani, MH & Abu-Raddad, LJ 2022, 'Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections', Journal of Travel Medicine. https://doi.org/10.1093/jtm/taac068

Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections. / Qassim, Suelen H; Chemaitelly, Hiam; Ayoub, Houssein H; AlMukdad, Sawsan; Tang, Patrick; Hasan, Mohammad R; Yassine, Hadi M; Al-Khatib, Hebah A; Smatti, Maria K; Abdul-Rahim, Hanan F; Nasrallah, Gheyath K; Al-Kuwari, Mohamed Ghaith; Al-Khal, Abdullatif; Coyle, Peter; Kaleeckal, Anvar Hassan; Shaik, Riyazuddin Mohammad; Latif, Ali Nizar; Al-Kuwari, Einas; Jeremijenko, Andrew; Butt, Adeel A; Bertollini, Roberto; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H; Abu-Raddad, Laith J.

In: Journal of Travel Medicine, 27.05.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections

AU - Qassim, Suelen H

AU - Chemaitelly, Hiam

AU - Ayoub, Houssein H

AU - AlMukdad, Sawsan

AU - Tang, Patrick

AU - Hasan, Mohammad R

AU - Yassine, Hadi M

AU - Al-Khatib, Hebah A

AU - Smatti, Maria K

AU - Abdul-Rahim, Hanan F

AU - Nasrallah, Gheyath K

AU - Al-Kuwari, Mohamed Ghaith

AU - Al-Khal, Abdullatif

AU - Coyle, Peter

AU - Kaleeckal, Anvar Hassan

AU - Shaik, Riyazuddin Mohammad

AU - Latif, Ali Nizar

AU - Al-Kuwari, Einas

AU - Jeremijenko, Andrew

AU - Butt, Adeel A

AU - Bertollini, Roberto

AU - Al-Romaihi, Hamad Eid

AU - Al-Thani, Mohamed H

AU - Abu-Raddad, Laith J

PY - 2022/5/27

Y1 - 2022/5/27

N2 - Compared to BA.1, BA.2 was associated with lower RT-qPCR cycle threshold (Ct) value—3.53 fewer cycles (95% CI: 3.46–3.60), signifying higher infectiousness. This may reflect higher viral load and/or longer duration of infection for BA.2. Natural immunity from previous infection and booster vaccination were associated with less infectious breakthrough infections.

AB - Compared to BA.1, BA.2 was associated with lower RT-qPCR cycle threshold (Ct) value—3.53 fewer cycles (95% CI: 3.46–3.60), signifying higher infectiousness. This may reflect higher viral load and/or longer duration of infection for BA.2. Natural immunity from previous infection and booster vaccination were associated with less infectious breakthrough infections.

KW - General Medicine

U2 - 10.1093/jtm/taac068

DO - 10.1093/jtm/taac068

M3 - Article

JO - Journal of Travel Medicine

JF - Journal of Travel Medicine

SN - 1195-1982

ER -

Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections

Abstract

Keywords

UN SDGs

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