Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress

Conor McClean; Ryan A. Harris; Malcolm Brown; John C. Brown; Gareth W. Davison

doi:10.1155/2015/723679

Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress

Conor McClean, Ryan A. Harris, Malcolm Brown, John C. Brown, Gareth W. Davison

School of Nursing and Midwifery

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

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Abstract

Purpose. To measure endothelial function and oxidative stress immediately, 90 minutes, and three hours after exercise of varying intensities. Methods. Sixteen apparently healthy men completed three exercise bouts of treadmill running for 30 minutes at 55% (mild); 20 minutes at 75% (moderate); or 5 minutes at 100% (maximal) in random order. Brachial artery flow-mediated dilation (FMD) was assessed with venous blood samples drawn for measurement of endothelin-1 (ET-1), lipid hydroperoxides (LOOHs), and lipid soluble antioxidants. Results. LOOH increased immediately following moderate exercise (). ET-1 was higher immediately after exercise and 3 hours after exercise in the mild trial compared to maximal one (). Transient decreases were detected for / from baseline following maximal exercise, but it normalised at 3 hours after exercise (). Shear rate was higher immediately after exercise in the maximal trial compared to mild exercise (). No changes in baseline diameter, peak diameter, absolute change in diameter, or FMD were observed following any of the exercise trials (). Conclusions. Acute exercise at different intensities elicits varied effects on oxidative stress, shear rate, and ET-1 that do not appear to mediate changes in endothelial function measured by FMD.

Original language	English
Article number	723679
Number of pages	8
Journal	Oxidative Medicine and Cellular Longevity
Volume	2015
DOIs	https://doi.org/10.1155/2015/723679
Publication status	Published - 2015

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10.1155/2015/723679Licence: CC BY

Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress
© 2015 The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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Cite this

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title = "Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress",

abstract = "Purpose. To measure endothelial function and oxidative stress immediately, 90 minutes, and three hours after exercise of varying intensities. Methods. Sixteen apparently healthy men completed three exercise bouts of treadmill running for 30 minutes at 55% (mild); 20 minutes at 75% (moderate); or 5 minutes at 100% (maximal) in random order. Brachial artery flow-mediated dilation (FMD) was assessed with venous blood samples drawn for measurement of endothelin-1 (ET-1), lipid hydroperoxides (LOOHs), and lipid soluble antioxidants. Results. LOOH increased immediately following moderate exercise (). ET-1 was higher immediately after exercise and 3 hours after exercise in the mild trial compared to maximal one (). Transient decreases were detected for / from baseline following maximal exercise, but it normalised at 3 hours after exercise (). Shear rate was higher immediately after exercise in the maximal trial compared to mild exercise (). No changes in baseline diameter, peak diameter, absolute change in diameter, or FMD were observed following any of the exercise trials (). Conclusions. Acute exercise at different intensities elicits varied effects on oxidative stress, shear rate, and ET-1 that do not appear to mediate changes in endothelial function measured by FMD.",

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doi = "10.1155/2015/723679",

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AU - Davison, Gareth W.

PY - 2015

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N2 - Purpose. To measure endothelial function and oxidative stress immediately, 90 minutes, and three hours after exercise of varying intensities. Methods. Sixteen apparently healthy men completed three exercise bouts of treadmill running for 30 minutes at 55% (mild); 20 minutes at 75% (moderate); or 5 minutes at 100% (maximal) in random order. Brachial artery flow-mediated dilation (FMD) was assessed with venous blood samples drawn for measurement of endothelin-1 (ET-1), lipid hydroperoxides (LOOHs), and lipid soluble antioxidants. Results. LOOH increased immediately following moderate exercise (). ET-1 was higher immediately after exercise and 3 hours after exercise in the mild trial compared to maximal one (). Transient decreases were detected for / from baseline following maximal exercise, but it normalised at 3 hours after exercise (). Shear rate was higher immediately after exercise in the maximal trial compared to mild exercise (). No changes in baseline diameter, peak diameter, absolute change in diameter, or FMD were observed following any of the exercise trials (). Conclusions. Acute exercise at different intensities elicits varied effects on oxidative stress, shear rate, and ET-1 that do not appear to mediate changes in endothelial function measured by FMD.

AB - Purpose. To measure endothelial function and oxidative stress immediately, 90 minutes, and three hours after exercise of varying intensities. Methods. Sixteen apparently healthy men completed three exercise bouts of treadmill running for 30 minutes at 55% (mild); 20 minutes at 75% (moderate); or 5 minutes at 100% (maximal) in random order. Brachial artery flow-mediated dilation (FMD) was assessed with venous blood samples drawn for measurement of endothelin-1 (ET-1), lipid hydroperoxides (LOOHs), and lipid soluble antioxidants. Results. LOOH increased immediately following moderate exercise (). ET-1 was higher immediately after exercise and 3 hours after exercise in the mild trial compared to maximal one (). Transient decreases were detected for / from baseline following maximal exercise, but it normalised at 3 hours after exercise (). Shear rate was higher immediately after exercise in the maximal trial compared to mild exercise (). No changes in baseline diameter, peak diameter, absolute change in diameter, or FMD were observed following any of the exercise trials (). Conclusions. Acute exercise at different intensities elicits varied effects on oxidative stress, shear rate, and ET-1 that do not appear to mediate changes in endothelial function measured by FMD.

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Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress

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