Effects of Folic Acid Supplementation on Serum Homocysteine Levels, Lipid Profiles, and Vascular Parameters in Post-Menopausal Korean Women with Type 2 Diabetes Mellitus

Aswathy Vijayakumar, Eun-kyung Kim, Hyesook Kim, Young Ju Choi, Kap Bum Huh, Namsoo Chang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily. Subjects' serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters.
Original languageEnglish
Pages (from-to)327-333
JournalNutrition Research and Practice
Volume11
Issue number4
Early online date18 Jul 2017
DOIs
Publication statusPublished - Aug 2017
Externally publishedYes

Fingerprint

menopause
homocysteine
Homocysteine
Folic Acid
noninsulin-dependent diabetes mellitus
blood vessels
folic acid
Type 2 Diabetes Mellitus
Blood Vessels
Lipids
vitamin B12
Vitamin B 12
lipids
Serum
Pulse Wave Analysis
Ankle
Arm
Diabetes Complications
low density lipoprotein cholesterol
high density lipoprotein cholesterol

Keywords

  • Folic Acid
  • LDL Cholesterol
  • Pulse Wave Velocity
  • Vitamin B12

Cite this

@article{e8fdd248ad684ea2807b07a206a094fa,
title = "Effects of Folic Acid Supplementation on Serum Homocysteine Levels, Lipid Profiles, and Vascular Parameters in Post-Menopausal Korean Women with Type 2 Diabetes Mellitus",
abstract = "BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily. Subjects' serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters.",
keywords = "Folic Acid, LDL Cholesterol, Pulse Wave Velocity, Vitamin B12",
author = "Aswathy Vijayakumar and Eun-kyung Kim and Hyesook Kim and Choi, {Young Ju} and Huh, {Kap Bum} and Namsoo Chang",
year = "2017",
month = "8",
doi = "10.4162/nrp.2017.11.4.327",
language = "English",
volume = "11",
pages = "327--333",
journal = "Nutrition Research and Practice",
issn = "1976-1457",
publisher = "The Korean Society of Community Nutrition",
number = "4",

}

Effects of Folic Acid Supplementation on Serum Homocysteine Levels, Lipid Profiles, and Vascular Parameters in Post-Menopausal Korean Women with Type 2 Diabetes Mellitus. / Vijayakumar, Aswathy; Kim, Eun-kyung ; Kim, Hyesook ; Choi, Young Ju ; Huh, Kap Bum ; Chang, Namsoo .

In: Nutrition Research and Practice, Vol. 11, No. 4, 08.2017, p. 327-333.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Folic Acid Supplementation on Serum Homocysteine Levels, Lipid Profiles, and Vascular Parameters in Post-Menopausal Korean Women with Type 2 Diabetes Mellitus

AU - Vijayakumar, Aswathy

AU - Kim, Eun-kyung

AU - Kim, Hyesook

AU - Choi, Young Ju

AU - Huh, Kap Bum

AU - Chang, Namsoo

PY - 2017/8

Y1 - 2017/8

N2 - BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily. Subjects' serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters.

AB - BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily. Subjects' serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters.

KW - Folic Acid

KW - LDL Cholesterol

KW - Pulse Wave Velocity

KW - Vitamin B12

U2 - 10.4162/nrp.2017.11.4.327

DO - 10.4162/nrp.2017.11.4.327

M3 - Article

VL - 11

SP - 327

EP - 333

JO - Nutrition Research and Practice

JF - Nutrition Research and Practice

SN - 1976-1457

IS - 4

ER -