Effects of Folic Acid Supplementation on Serum Homocysteine Levels, Lipid Profiles, and Vascular Parameters in Post-Menopausal Korean Women with Type 2 Diabetes Mellitus

Aswathy Vijayakumar, Eun-kyung Kim, Hyesook Kim, Young Ju Choi, Kap Bum Huh, Namsoo Chang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily. Subjects' serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters.
Original languageEnglish
Pages (from-to)327-333
JournalNutrition Research and Practice
Volume11
Issue number4
Early online date18 Jul 2017
DOIs
Publication statusPublished - Aug 2017
Externally publishedYes

Keywords

  • Folic Acid
  • LDL Cholesterol
  • Pulse Wave Velocity
  • Vitamin B12

Fingerprint Dive into the research topics of 'Effects of Folic Acid Supplementation on Serum Homocysteine Levels, Lipid Profiles, and Vascular Parameters in Post-Menopausal Korean Women with Type 2 Diabetes Mellitus'. Together they form a unique fingerprint.

Cite this