Effects of modified low-density lipoproteins on human retinal pericyte survival

Weiwei Song, Jeremy L Barth, Kangmo Lu, Yongxin Yu, Yan Huang, Cynthia K Gittinger, W Scott Argraves, Timothy J Lyons

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heavily oxidized glycated LDL (HOG-LDL). We demonstrate here that modified LDL inhibits the proliferation and survival of cultured human retinal pericytes. Modified LDL also induced DNA fragmentation in bovine retinal pericytes. Overall, HOG-LDL produced a significantly higher extent of cytotoxicity and apoptosis in retinal pericytes. These results indicate that exposure of pericytes to HOG-LDL could be implicated in the development of diabetic retinopathy.
Original languageEnglish
Pages (from-to)390-5
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1043
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Apoptosis
  • Cell Survival
  • DNA Fragmentation
  • Humans
  • Lipoproteins, LDL
  • Pericytes
  • Retina

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