Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes

Weiwei Song, Jeremy L Barth, Yongxin Yu, Kangmo Lu, Azar Dashti, Yan Huang, Cynthia K Gittinger, W Scott Argraves, Timothy J Lyons

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Modified (oxidized and/or glycated) low-density lipoproteins (LDLs) have been implicated in retinal pericyte loss, one of the major pathologic features of early-stage diabetic retinopathy. To delineate underlying molecular mechanisms, the present study was designed to explore the global effects of modified LDL on pericyte gene expression.
Original languageEnglish
Pages (from-to)2974-82
Number of pages9
JournalInvestigative ophthalmology & visual science
Volume46
Issue number8
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Adult
  • Capillaries
  • Gene Expression
  • Gene Expression Profiling
  • Humans
  • Lipoproteins, LDL
  • Oligonucleotide Array Sequence Analysis
  • Pericytes
  • Retinal Vessels
  • Reverse Transcriptase Polymerase Chain Reaction

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