Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes

Weiwei Song; Jeremy L Barth; Yongxin Yu; Kangmo Lu; Azar Dashti; Yan Huang; Cynthia K Gittinger; W Scott Argraves; Timothy J Lyons

doi:10.1167/iovs.04-1505

Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes

Weiwei Song
, Jeremy L Barth
, Yongxin Yu
, Kangmo Lu
, Azar Dashti
, Yan Huang
, Cynthia K Gittinger
, W Scott Argraves
, Timothy J Lyons

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Modified (oxidized and/or glycated) low-density lipoproteins (LDLs) have been implicated in retinal pericyte loss, one of the major pathologic features of early-stage diabetic retinopathy. To delineate underlying molecular mechanisms, the present study was designed to explore the global effects of modified LDL on pericyte gene expression.

Original language	English
Pages (from-to)	2974-82
Number of pages	9
Journal	Investigative ophthalmology & visual science
Volume	46
Issue number	8
DOIs	https://doi.org/10.1167/iovs.04-1505
Publication status	Published - Aug 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Capillaries
Gene Expression
Gene Expression Profiling
Humans
Lipoproteins, LDL
Oligonucleotide Array Sequence Analysis
Pericytes
Retinal Vessels
Reverse Transcriptase Polymerase Chain Reaction

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10.1167/iovs.04-1505

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title = "Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes",

abstract = "Modified (oxidized and/or glycated) low-density lipoproteins (LDLs) have been implicated in retinal pericyte loss, one of the major pathologic features of early-stage diabetic retinopathy. To delineate underlying molecular mechanisms, the present study was designed to explore the global effects of modified LDL on pericyte gene expression.",

keywords = "Adult, Capillaries, Gene Expression, Gene Expression Profiling, Humans, Lipoproteins, LDL, Oligonucleotide Array Sequence Analysis, Pericytes, Retinal Vessels, Reverse Transcriptase Polymerase Chain Reaction",

author = "Weiwei Song and Barth, \{Jeremy L\} and Yongxin Yu and Kangmo Lu and Azar Dashti and Yan Huang and Gittinger, \{Cynthia K\} and Argraves, \{W Scott\} and Lyons, \{Timothy J\}",

year = "2005",

month = aug,

doi = "10.1167/iovs.04-1505",

language = "English",

volume = "46",

pages = "2974--82",

journal = "Investigative ophthalmology \& visual science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "8",

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TY - JOUR

T1 - Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes

AU - Song, Weiwei

AU - Barth, Jeremy L

AU - Yu, Yongxin

AU - Lu, Kangmo

AU - Dashti, Azar

AU - Huang, Yan

AU - Gittinger, Cynthia K

AU - Argraves, W Scott

AU - Lyons, Timothy J

PY - 2005/8

Y1 - 2005/8

N2 - Modified (oxidized and/or glycated) low-density lipoproteins (LDLs) have been implicated in retinal pericyte loss, one of the major pathologic features of early-stage diabetic retinopathy. To delineate underlying molecular mechanisms, the present study was designed to explore the global effects of modified LDL on pericyte gene expression.

AB - Modified (oxidized and/or glycated) low-density lipoproteins (LDLs) have been implicated in retinal pericyte loss, one of the major pathologic features of early-stage diabetic retinopathy. To delineate underlying molecular mechanisms, the present study was designed to explore the global effects of modified LDL on pericyte gene expression.

KW - Adult

KW - Capillaries

KW - Gene Expression

KW - Gene Expression Profiling

KW - Humans

KW - Lipoproteins, LDL

KW - Oligonucleotide Array Sequence Analysis

KW - Pericytes

KW - Retinal Vessels

KW - Reverse Transcriptase Polymerase Chain Reaction

U2 - 10.1167/iovs.04-1505

DO - 10.1167/iovs.04-1505

M3 - Article

C2 - 16043874

SN - 0146-0404

VL - 46

SP - 2974

EP - 2982

JO - Investigative ophthalmology & visual science

JF - Investigative ophthalmology & visual science

IS - 8

ER -

Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes

Abstract

UN SDGs

Keywords

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