Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

N. Irwin; V.A. Gault; Brian Green; Brett Greer; J.T. McCluskey; Patrick Harriott; F.P.M. OHarte; P.R. Flatt

doi:10.1515/BC.2004.110

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

N. Irwin, V.A. Gault, Brian Green, Brett Greer, J.T. McCluskey, Patrick Harriott, F.P.M. OHarte, P.R. Flatt

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Glucosedependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p

Original language	English
Pages (from-to)	845-852
Number of pages	8
Journal	Biological Chemistry
Volume	385
Issue number	9
DOIs	https://doi.org/10.1515/BC.2004.110
Publication status	Published - Sep 2004

ASJC Scopus subject areas

Biochemistry

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10.1515/BC.2004.110

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AU - Greer, Brett

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AU - Harriott, Patrick

AU - OHarte, F.P.M.

AU - Flatt, P.R.

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Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Abstract

ASJC Scopus subject areas

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