Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

N. Irwin, V.A. Gault, Brian Green, Brett Greer, J.T. McCluskey, Patrick Harriott, F.P.M. OHarte, P.R. Flatt

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Glucosedependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p
Original languageEnglish
Pages (from-to)845-852
Number of pages8
JournalBiological Chemistry
Volume385
Issue number9
DOIs
Publication statusPublished - Sep 2004

ASJC Scopus subject areas

  • Biochemistry

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