Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

N. Irwin; V.A. Gault; Brian Green; Brett Greer; J.T. McCluskey; Patrick Harriott; F.P.M. OHarte; P.R. Flatt

doi:10.1515/BC.2004.110

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

N. Irwin
, V.A. Gault
, Brian Green
, Brett Greer
, J.T. McCluskey
, Patrick Harriott
, F.P.M. OHarte
, P.R. Flatt

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Glucosedependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p

Original language	English
Pages (from-to)	845-852
Number of pages	8
Journal	Biological Chemistry
Volume	385
Issue number	9
DOIs	https://doi.org/10.1515/BC.2004.110
Publication status	Published - Sept 2004

ASJC Scopus subject areas

Biochemistry

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10.1515/BC.2004.110

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AU - Gault, V.A.

AU - Green, Brian

AU - Greer, Brett

AU - McCluskey, J.T.

AU - Harriott, Patrick

AU - OHarte, F.P.M.

AU - Flatt, P.R.

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AB - Glucosedependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p

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DO - 10.1515/BC.2004.110

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Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Abstract

ASJC Scopus subject areas

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