Efficacy of pharmacotherapy and non-pharmacotherapy of Alzheimer dementia: A protocol for systematic review and meta-analysis

Chitima Boongird*, Worapong Tearneukit, Wannisa Wongpipathpong, Gareth J McKay, Ammarin Thakkinstian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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BACKGROUND: Alzheimer disease (AD) is the most common cause of dementia worldwide. Despite the publication of numerous systematic reviews and meta-analyses that have summarized the evidence associated with pharmacotherapies (PTs) and non-pharmacotherapies (NPTs) for the wide range of interventions available for AD treatment, their comparative safety and efficacy remains insufficiently defined.

METHODS: Systematic reviews of randomized controlled trials (RCTs) will be selected according to the following criteria: conducted in elderly patients aged 60 years or older with AD living in community or institutionalized settings, applied pairwise meta-analysis (PMA) or network meta-analysis (NMA) approaches providing pooled relative treatment effects for at least 1 pair of PTs or NPTs, and providing at least 1 of the following outcomes for patients/caregivers: cognitive, functional status, behavior, quality of life (QoL), and caregiver stress or burden. All article screening, data extraction, and risk of bias assessment will be completed independently by 2 reviewers. Relative treatment rankings will be reported with mean ranks and surface under the cumulative ranking curves.

RESULTS AND CONCLUSION: We will determine the most efficacious treatment strategies for AD patients from the most highly ranked treatments. These results will help to guide clinical decision-making and improve patient care.

Original languageEnglish
Article numbere32382
Number of pages6
Issue number50
Publication statusPublished - 16 Dec 2022

Bibliographical note

Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.


  • Aged
  • Humans
  • Alzheimer Disease/drug therapy
  • Systematic Reviews as Topic
  • Meta-Analysis as Topic
  • Treatment Outcome
  • Network Meta-Analysis


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