Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen van den Bossche, Wafa' T Al-Jamal, Bowen Tian, Antonio Nunes, Chiara Fabbro, Alberto Bianco, Maurizio Prato, Kostas Kostarelos

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.

Original languageEnglish
Pages (from-to)7379-81
Number of pages3
JournalChemical Communications
Volume46
Issue number39
DOIs
Publication statusPublished - 21 Oct 2010

Keywords

  • Aptamers, Nucleotide
  • Base Sequence
  • Biological Transport
  • Cell Line, Tumor
  • DNA Primers
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Microscopy, Electron, Transmission
  • Nanotubes, Carbon
  • Receptors, Cell Surface
  • Journal Article
  • Research Support, Non-U.S. Gov't

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