Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen van den Bossche; Wafa' T Al-Jamal; Bowen Tian; Antonio Nunes; Chiara Fabbro; Alberto Bianco; Maurizio Prato; Kostas Kostarelos

doi:10.1039/c0cc02092c

Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen van den Bossche, Wafa' T Al-Jamal, Bowen Tian, Antonio Nunes, Chiara Fabbro, Alberto Bianco, Maurizio Prato, Kostas Kostarelos

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.

Original language	English
Pages (from-to)	7379-81
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	39
DOIs	https://doi.org/10.1039/c0cc02092c
Publication status	Published - 21 Oct 2010

Keywords

Aptamers, Nucleotide
Base Sequence
Biological Transport
Cell Line, Tumor
DNA Primers
Electrophoresis, Polyacrylamide Gel
Humans
Microscopy, Electron, Transmission
Nanotubes, Carbon
Receptors, Cell Surface
Journal Article
Research Support, Non-U.S. Gov't

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10.1039/c0cc02092c

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title = "Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes",

abstract = "We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.",

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Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes. / van den Bossche, Jeroen; Al-Jamal, Wafa' T; Tian, Bowen; Nunes, Antonio; Fabbro, Chiara; Bianco, Alberto; Prato, Maurizio; Kostarelos, Kostas.

In: Chemical Communications, Vol. 46, No. 39, 21.10.2010, p. 7379-81.

Research output: Contribution to journal › Article › peer-review

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AU - van den Bossche, Jeroen

AU - Al-Jamal, Wafa' T

AU - Tian, Bowen

AU - Nunes, Antonio

AU - Fabbro, Chiara

AU - Bianco, Alberto

AU - Prato, Maurizio

AU - Kostarelos, Kostas

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KW - Base Sequence

KW - Biological Transport

KW - Cell Line, Tumor

KW - DNA Primers

KW - Electrophoresis, Polyacrylamide Gel

KW - Humans

KW - Microscopy, Electron, Transmission

KW - Nanotubes, Carbon

KW - Receptors, Cell Surface

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1039/c0cc02092c

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