Abstract
We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.
Original language | English |
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Pages (from-to) | 7379-81 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 46 |
Issue number | 39 |
DOIs | |
Publication status | Published - 21 Oct 2010 |
Keywords
- Aptamers, Nucleotide
- Base Sequence
- Biological Transport
- Cell Line, Tumor
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Humans
- Microscopy, Electron, Transmission
- Nanotubes, Carbon
- Receptors, Cell Surface
- Journal Article
- Research Support, Non-U.S. Gov't