Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen van den Bossche; Wafa' T Al-Jamal; Bowen Tian; Antonio Nunes; Chiara Fabbro; Alberto Bianco; Maurizio Prato; Kostas Kostarelos

doi:10.1039/c0cc02092c

Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen van den Bossche, Wafa' T Al-Jamal, Bowen Tian, Antonio Nunes, Chiara Fabbro, Alberto Bianco, Maurizio Prato, Kostas Kostarelos

School of Pharmacy

Research output: Contribution to journal › Article

33 Citations (Scopus)

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.

Original language	English
Pages (from-to)	7379-81
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	39
DOIs	https://doi.org/10.1039/c0cc02092c
Publication status	Published - 21 Oct 2010

Keywords

Aptamers, Nucleotide
Base Sequence
Biological Transport
Cell Line, Tumor
DNA Primers
Electrophoresis, Polyacrylamide Gel
Humans
Microscopy, Electron, Transmission
Nanotubes, Carbon
Receptors, Cell Surface
Journal Article
Research Support, Non-U.S. Gov't

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10.1039/c0cc02092c

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van den Bossche, J., Al-Jamal, W. T., Tian, B., Nunes, A., Fabbro, C., Bianco, A., Prato, M., & Kostarelos, K. (2010). Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes. Chemical Communications, 46(39), 7379-81. https://doi.org/10.1039/c0cc02092c

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Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes. / van den Bossche, Jeroen; Al-Jamal, Wafa' T; Tian, Bowen; Nunes, Antonio; Fabbro, Chiara; Bianco, Alberto; Prato, Maurizio; Kostarelos, Kostas.

In: Chemical Communications, Vol. 46, No. 39, 21.10.2010, p. 7379-81.

Research output: Contribution to journal › Article

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KW - Electrophoresis, Polyacrylamide Gel

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KW - Microscopy, Electron, Transmission

KW - Nanotubes, Carbon

KW - Receptors, Cell Surface

KW - Journal Article

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