Elafin prevents lipopolysaccharide-induced AP-1 and NF-kB activation via an effect on the ubiquitin-proteasome pathway

M.W. Butler, S.J. O'Neill, N.G. McElvaney, I. Robertson, C.M. Greene, Clifford Taggart

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

In this paper we follow on from our research into SLPI by assessing the immunomodulatory activity of elafin - an antiprotease related to SLPI and also present on the respiratory tract. We demonstrate for the first time that exogenously applied elafin inhibits lipopolysaccharide-induced activation of the NF-kappaB and AP-1 pathways in monocytes. I designed this project and supervised Marcus Butler during his MD thesis.
Original languageEnglish
Pages (from-to)34730-34735
Number of pages6
JournalJournal of Biological Chemistry
Volume281(46)
Issue number46
DOIs
Publication statusPublished - 17 Nov 2006

ASJC Scopus subject areas

  • Biochemistry

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