Elafin prevents lipopolysaccharide-induced AP-1 and NF-kB activation via an effect on the ubiquitin-proteasome pathway

M.W. Butler; S.J. O'Neill; N.G. McElvaney; I. Robertson; C.M. Greene; Clifford Taggart

doi:10.1074/jbc.M604844200

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kB activation via an effect on the ubiquitin-proteasome pathway

M.W. Butler
, S.J. O'Neill
, N.G. McElvaney
, I. Robertson
, C.M. Greene
, Clifford Taggart

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

In this paper we follow on from our research into SLPI by assessing the immunomodulatory activity of elafin - an antiprotease related to SLPI and also present on the respiratory tract. We demonstrate for the first time that exogenously applied elafin inhibits lipopolysaccharide-induced activation of the NF-kappaB and AP-1 pathways in monocytes. I designed this project and supervised Marcus Butler during his MD thesis.

Original language	English
Pages (from-to)	34730-34735
Number of pages	6
Journal	Journal of Biological Chemistry
Volume	281(46)
Issue number	46
DOIs	https://doi.org/10.1074/jbc.M604844200
Publication status	Published - 17 Nov 2006

ASJC Scopus subject areas

Biochemistry

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10.1074/jbc.M604844200

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title = "Elafin prevents lipopolysaccharide-induced AP-1 and NF-kB activation via an effect on the ubiquitin-proteasome pathway",

abstract = "In this paper we follow on from our research into SLPI by assessing the immunomodulatory activity of elafin - an antiprotease related to SLPI and also present on the respiratory tract. We demonstrate for the first time that exogenously applied elafin inhibits lipopolysaccharide-induced activation of the NF-kappaB and AP-1 pathways in monocytes. I designed this project and supervised Marcus Butler during his MD thesis.",

author = "M.W. Butler and S.J. O'Neill and N.G. McElvaney and I. Robertson and C.M. Greene and Clifford Taggart",

year = "2006",

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T1 - Elafin prevents lipopolysaccharide-induced AP-1 and NF-kB activation via an effect on the ubiquitin-proteasome pathway

AU - Butler, M.W.

AU - O'Neill, S.J.

AU - McElvaney, N.G.

AU - Robertson, I.

AU - Greene, C.M.

AU - Taggart, Clifford

PY - 2006/11/17

Y1 - 2006/11/17

N2 - In this paper we follow on from our research into SLPI by assessing the immunomodulatory activity of elafin - an antiprotease related to SLPI and also present on the respiratory tract. We demonstrate for the first time that exogenously applied elafin inhibits lipopolysaccharide-induced activation of the NF-kappaB and AP-1 pathways in monocytes. I designed this project and supervised Marcus Butler during his MD thesis.

AB - In this paper we follow on from our research into SLPI by assessing the immunomodulatory activity of elafin - an antiprotease related to SLPI and also present on the respiratory tract. We demonstrate for the first time that exogenously applied elafin inhibits lipopolysaccharide-induced activation of the NF-kappaB and AP-1 pathways in monocytes. I designed this project and supervised Marcus Butler during his MD thesis.

UR - https://www.scopus.com/pages/publications/33845953446

U2 - 10.1074/jbc.M604844200

DO - 10.1074/jbc.M604844200

M3 - Article

SN - 0021-9258

VL - 281(46)

SP - 34730

EP - 34735

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 46

ER -

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kB activation via an effect on the ubiquitin-proteasome pathway

Abstract

ASJC Scopus subject areas

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