Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation towards osteogenic outcomes

John G. Hardy, Maria K. Villancio-Wolter, Rushi C. Sukhavasi, David J. Mouser, David Aguilar Jr., Sydney A. Geissler, David L. Kaplan, Christine E. Schmidt

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Tissue scaffolds allowing the behaviour of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein we describe the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation towards osteogenic outcomes.
Original languageEnglish
Pages (from-to)1884-1890
Number of pages7
JournalMacromolecular Rapid Communications
Volume36
Issue number21
Early online date06 Jul 2015
Publication statusPublished - Nov 2015
Externally publishedYes

Keywords

  • conducting polymers
  • electrical stimulation
  • tissue scaffold
  • stem cells
  • bone

ASJC Scopus subject areas

  • Bioengineering
  • Electrochemistry
  • Biomaterials

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