Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation towards osteogenic outcomes

John G. Hardy; Maria K. Villancio-Wolter; Rushi C. Sukhavasi; David J. Mouser; David Aguilar Jr.; Sydney A. Geissler; David L. Kaplan; Christine E. Schmidt

Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation towards osteogenic outcomes

John G. Hardy
, Maria K. Villancio-Wolter
, Rushi C. Sukhavasi
, David J. Mouser
, David Aguilar Jr.
, Sydney A. Geissler
, David L. Kaplan
, Christine E. Schmidt

Research output: Contribution to journal › Article › peer-review

Abstract

Tissue scaffolds allowing the behaviour of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein we describe the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation towards osteogenic outcomes.

Original language	English
Pages (from-to)	1884-1890
Number of pages	7
Journal	Macromolecular Rapid Communications
Volume	36
Issue number	21
Early online date	06 Jul 2015
Publication status	Published - Nov 2015
Externally published	Yes

Keywords

conducting polymers
electrical stimulation
tissue scaffold
stem cells
bone

ASJC Scopus subject areas

Bioengineering
Electrochemistry
Biomaterials

Cite this

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title = "Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation towards osteogenic outcomes",

abstract = "Tissue scaffolds allowing the behaviour of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein we describe the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation towards osteogenic outcomes.",

keywords = "conducting polymers, electrical stimulation, tissue scaffold, stem cells, bone",

author = "Hardy, \{John G.\} and Villancio-Wolter, \{Maria K.\} and Sukhavasi, \{Rushi C.\} and Mouser, \{David J.\} and \{Aguilar Jr.\}, David and Geissler, \{Sydney A.\} and Kaplan, \{David L.\} and Schmidt, \{Christine E.\}",

year = "2015",

month = nov,

language = "English",

volume = "36",

pages = "1884--1890",

journal = "Macromolecular Rapid Communications",

issn = "1022-1336",

publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation towards osteogenic outcomes

AU - Hardy, John G.

AU - Villancio-Wolter, Maria K.

AU - Sukhavasi, Rushi C.

AU - Mouser, David J.

AU - Aguilar Jr., David

AU - Geissler, Sydney A.

AU - Kaplan, David L.

AU - Schmidt, Christine E.

PY - 2015/11

Y1 - 2015/11

N2 - Tissue scaffolds allowing the behaviour of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein we describe the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation towards osteogenic outcomes.

AB - Tissue scaffolds allowing the behaviour of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein we describe the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation towards osteogenic outcomes.

KW - conducting polymers

KW - electrical stimulation

KW - tissue scaffold

KW - stem cells

KW - bone

M3 - Article

SN - 1022-1336

VL - 36

SP - 1884

EP - 1890

JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

IS - 21

ER -

Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation towards osteogenic outcomes

Abstract

Keywords

ASJC Scopus subject areas

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