Electrospun amorphous medicated nanocomposites fabricated using a Teflon-based concentric spinneret

Qing Wang, Deng Guang Yu*, Sun Yi Zhou, Chen Li, Min Zhao

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Facile methods to improve the dissolution rate of poorly water-soluble drugs are highly sought after. In this study, a modified coaxial electrospinning process was exploited to create medicated amorphous nanocomposites, an approach characterized by the application of a Teflon-coated coaxial spinneret. The hydrophilic polymer hydroxypropyl methylcellulose and the active ingredient tamoxifen citrate (TAM) were selected as the drug carrier and model drug, respectively. Their electrospun nanocomposites showed linear morphology with the drug presented in an amorphous state. The loaded cargoes could be released from the nanocomposites simultaneously when they were placed in the dissolution media, showing faster dissolution rates than their counterparts (physical mixtures). Based on the reasonable application of the polymeric carrier, the reported protocols not only provided an approach to enhance the dissolution of poorly water-soluble drugs, but also exhibited a method to facilitate the implementation of coaxial electrospinning.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
Journale-Polymers
Volume18
Issue number1
Early online date18 Aug 2017
DOIs
Publication statusPublished - 26 Jan 2018

Keywords

  • Modified coaxial electrospinning
  • nanocomposite
  • polymeric composite
  • poorly water-soluble drug
  • Teflon

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Physical and Theoretical Chemistry
  • Polymers and Plastics

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