Elevated virulence of an emerging viral genotype as a driver of honeybee loss

Dino P McMahon, Myrsini E Natsopoulou, Vincent Doublet, Matthias Fürst, Silvio Weging, Mark J F Brown, Andreas Gogol-Döring, Robert J Paxton

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116 Citations (Scopus)
255 Downloads (Pure)

Abstract

Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity crisis, leading to widespread epidemics and population loss. Owing to genetic variation in pathogen virulence, a complete understanding of species decline requires the accurate identification and characterization of EIDs. We explore this issue in the Western honeybee, where increasing mortality of populations in the Northern Hemisphere has caused major concern. Specifically, we investigate the importance of genetic identity of the main suspect in mortality, deformed wing virus (DWV), in driving honeybee loss. Using laboratory experiments and a systematic field survey, we demonstrate that an emerging DWV genotype (DWV-B) is more virulent than the established DWV genotype (DWV-A) and is widespread in the landscape. Furthermore, we show in a simple model that colonies infected with DWV-B collapse sooner than colonies infected with DWV-A. We also identify potential for rapid DWV evolution by revealing extensive genome-wide recombination in vivo The emergence of DWV-B in naive honeybee populations, including via recombination with DWV-A, could be of significant ecological and economic importance. Our findings emphasize that knowledge of pathogen genetic identity and diversity is critical to understanding drivers of species decline.

Original languageEnglish
Number of pages8
JournalProceedings. Biological sciences / The Royal Society
Volume283
Issue number1833
DOIs
Publication statusPublished - 29 Jun 2016
Externally publishedYes

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