Elucidating the pathogenesis of pre-eclampsia using in vitro models of spiral uterine artery remodelling

Ross McNally, Abdelrahim Alqudah, Danilo Obradovic, Lana McClements

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Purpose of review: To perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed.
Recent findings: A number of proteins and micro-RNAs have been implicated as key in SUA remodelling, which could be explored as early biomarkers or therapeutic targets for prevention of pre-eclampsia.
Summary: Various 2D and 3D in vitro models involving trophoblast cells, endothelial cells, immune cells and placental tissue have been utilised to elucidate the pathogenesis of pre-eclampsia. Nevertheless, pre-eclampsia is a multifactorial disease and the mechanisms involved in its pathogenesis are complex and still largely unknown. Further studies are required to provide better understanding of the key processes leading to inappropriate placental development which is the root cause of pre-eclampsia. This new knowledge could identify novel biomarkers and treatment strategies.
Original languageEnglish
JournalCurrent Hypertension Reports
Early online date23 Oct 2017
Publication statusPublished - 01 Nov 2017


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