This chapter examines key concepts with respect to the use of nucleic acids for bone regeneration and the unique challenges that occur with respect to the delivery of this cargo. This chapter will highlight the biological and molecular barriers that need to be overcome before effective nonviral delivery systems can be appropriately designed for bone repair applications. The chapter will then go on to examine the cargo to be delivered focusing on DNA, mRNA, and siRNA therapeutics. Finally, this chapter focuses on future directions with a growing body of evidence that supports the use of microRNA to target multiple pathways involved in bone regeneration. The use of miRNA with a multifunctional delivery provides a series of third-generation therapeutics for bone repair.
|Title of host publication||Bone Repair Materials|
|Publication status||Published - 11 Jan 2019|