Enantioselective dioxygenase-catalysed formation and thermal racemisation of chiral thiophene sulfoxides

Derek Boyd, Narain Sharma, S.A. Haughey, John Malone, B.T. McMurray, Gary Sheldrake, Christopher Allen, H. Dalton

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Substituted chiral thiophene 1-oxides and their cycloadducts of variable enantiopurity have been isolated as products of dioxygenase-catalysed sulfoxidation of the corresponding thiophenes using intact cells of Pseudomonas putida; thermal racemization (Delta G(double dagger) = 25.1 kcal mol(-1)) of the enantiopure metabolite (1R)-2-methylbenzo[b]thiophene 1-oxide has been observed.
Original languageEnglish
Pages (from-to)2363-2364
Number of pages2
JournalChemical Communications
VolumeNA
Publication statusPublished - 1996

Fingerprint

Dive into the research topics of 'Enantioselective dioxygenase-catalysed formation and thermal racemisation of chiral thiophene sulfoxides'. Together they form a unique fingerprint.

Cite this