Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

Peter C. Knipe; Martin D. Smith

doi:10.1039/c4ob00627e

Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

Peter C. Knipe, Martin D. Smith^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

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Abstract

A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst.

Original language	English
Pages (from-to)	5094-5097
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	28
Early online date	13 Jun 2014
DOIs	https://doi.org/10.1039/c4ob00627e
Publication status	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry
Medicine(all)

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10.1039/c4ob00627eLicence: Unspecified

Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis
This journal is © The Royal Society of Chemistry, 2014. This is the accepted manuscript version of the article. The final version is available online from the Royal Society of Chemistry at: [http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/c4ob00627e#!divAbstract
Accepted author manuscript, 789 KBLicence: Unspecified

Cite this

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abstract = "A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst. ",

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AB - A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst.

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Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

Abstract

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Peter Knipe

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Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

Abstract

ASJC Scopus subject areas

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Peter Knipe

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