Enantioselective Rhodium-Catalyzed Alkylative Desymmetrization of 3,5-Dimethylglutaric Anhydride

Matthew Cook, T. Rovis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A rhodium-catalyzed enantioselective cross-coupling of sp³ organozinc reagents and 3,5-dimethylglutaric anhydride has been developed to afford the corresponding products, syn-deoxypolypropionates, in excellent yields and enantioselectivities. This reaction has been developed so that both commercially available and in situ prepared organozinc reagents are competent coupling partners.
Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalSynthesis
Volume2
Issue number2
Early online date12 Dec 2008
DOIs
Publication statusPublished - 16 Jan 2009

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Rhodium
Anhydrides
Enantioselectivity
syn-deoxypolypropionate

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Cook, Matthew ; Rovis, T. / Enantioselective Rhodium-Catalyzed Alkylative Desymmetrization of 3,5-Dimethylglutaric Anhydride. In: Synthesis. 2009 ; Vol. 2, No. 2. pp. 335-338.
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Enantioselective Rhodium-Catalyzed Alkylative Desymmetrization of 3,5-Dimethylglutaric Anhydride. / Cook, Matthew; Rovis, T.

In: Synthesis, Vol. 2, No. 2, 16.01.2009, p. 335-338.

Research output: Contribution to journalArticle

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