Endocrine disruptor activity of multiple environmental food chain contaminants

E. Wielogórska, C. T. Elliott, M. Danaher, L. Connolly*, Lisa Connolly

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Industrial chemicals, antimicrobials, drugs and personal care products have been reported as global pollutants which enter the food chain. Some of them have also been classified as endocrine disruptors based on results of various studies employing a number of in vitro/. vivo tests. The present study employed a mammalian reporter gene assay to assess the effects of known and emerging contaminants on estrogen nuclear receptor transactivation.Out of fifty-nine compounds assessed, estrogen receptor agonistic activity was observed for parabens (. n= 3), UV filters (. n= 6), phthalates (. n= 4) and a metabolite, pyrethroids (. n= 9) and their metabolites (. n= 3). Two compounds were estrogen receptor antagonists while some of the agonists enhanced 17β-estradiol mediated response.This study reports five new compounds (pyrethroids and their metabolites) possessing estrogen agonist activity and highlights for the first time that pyrethroid metabolites are of particular concern showing much greater estrogenic activity than their parent compounds.

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalToxicology in Vitro
Volume29
Issue number1
Early online date28 Oct 2014
DOIs
Publication statusPublished - 01 Feb 2015

Keywords

  • Antimicrobial
  • Endocrine disruptor
  • Industrial chemical
  • Personal care product
  • Preservative
  • Reporter gene assay

ASJC Scopus subject areas

  • Toxicology

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