Endothelial Progenitors as Tools to Study Vascular Disease

Reinhold J. Medina, Christina L. O'Neill, T. Michelle O'Doherty, Sarah E. J. Wilson, Alan W. Stitt

Research output: Contribution to journalArticle

21 Citations (Scopus)
220 Downloads (Pure)

Abstract

Endothelial progenitor cells (EPCs) have great clinical value because they can be used as diagnostic biomarkers and as a cellular therapy for promoting vascular repair of ischaemic tissues. However, EPCs also have an additional research value in vascular disease modelling to interrogate human disease mechanisms. The term EPC is used to describe a diverse variety of cells, and we have identified a specific EPC subtype called outgrowth endothelial cell (OEC) as the best candidate for vascular disease modelling because of its high-proliferative potential and unambiguous endothelial commitment. OECs are isolated from human blood and can be exposed to pathologic conditions (forward approach) or be isolated from patients (reverse approach) in order to study vascular human disease. The use of OECs for modelling vascular disease will contribute greatly to improving our understanding of endothelial pathogenesis, which will potentially lead to the discovery of novel therapeutic strategies for vascular diseases.
Original languageEnglish
Article number346735
Pages (from-to)1-5
JournalStem Cells International
Volume2012
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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