Endothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in rats.

Alexander Thompson, C.R. Valeri, W. Lieberthal

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We examined the extent to which the systemic and renal vasoconstriction induced by nitric oxide (NO) inhibition in vivo is mediated by endothelin (ET). We examined the effects of BQ-610, a specific ETA-receptor antagonist, after NO inhibition with N omega-nitro-L-arginine methyl ester (L-NAME) in the anesthetized rat. Mean arterial pressure (MAP) increased after L-NAME infusion from 107 +/- 2 to 133 +/- 3 mmHg (P
Original languageEnglish
Pages (from-to)H743-8
Number of pages6
JournalThe American journal of physiology
Volume269(2 Pt 2)
Publication statusPublished - 1995

Fingerprint Dive into the research topics of 'Endothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in rats.'. Together they form a unique fingerprint.

  • Cite this