We examined the extent to which the systemic and renal vasoconstriction induced by nitric oxide (NO) inhibition in vivo is mediated by endothelin (ET). We examined the effects of BQ-610, a specific ETA-receptor antagonist, after NO inhibition with N omega-nitro-L-arginine methyl ester (L-NAME) in the anesthetized rat. Mean arterial pressure (MAP) increased after L-NAME infusion from 107 +/- 2 to 133 +/- 3 mmHg (P
|Number of pages||6|
|Journal||The American journal of physiology|
|Volume||269(2 Pt 2)|
|Publication status||Published - 1995|
Thompson, A., Valeri, C. R., & Lieberthal, W. (1995). Endothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in rats. The American journal of physiology, 269(2 Pt 2), H743-8.