This paper investigates the performance of energy detection-based spectrum sensing over Fisher-Snedecor F fading channels. To this end, an analytical expression for the corre- sponding average detection probability is firstly derived and then this is extended to account for collaborative spectrum sensing. The complementary receiver operating characteristics (ROC) are analyzed for different conditions of the average signal-to- noise ratio (SNR), time-bandwidth product, multipath fading, shadowing and number of collaborating users. It is shown that the energy detection performance is strongly linked to the severity of the multipath fading and amount of shadowing, whereby even small variations in either of these physical phenomena significantly impact the detection probability. Also, the versatile modeling capability of the Fisher-Snedecor F distribution is veridfied in the context of energy detection based spectrum sensing as it provides considerably more accurate characterization than the conventional Rayleigh fading model. To confirm the validity of the analytical results presented in this paper, we compare them with the results of some simulations.