Engineered exosomes for cancer theranostics: next-generation tumor targeting

Vivek P. Chavda; Vrashabh V.  Sugandhi; Chandrakantsing V.  Pardeshi; Rahul Jaywant  Patil; Mit  Joshi; Bhoomika  Patel; Avinash Khadela; Rajashri Bezbaruah; Bedanta Bhattacharjee; Pankti C. Balar; Lalitkumar K. Vora

doi:10.1016/j.jddst.2023.104579

Engineered exosomes for cancer theranostics: next-generation tumor targeting

Vivek P. Chavda^*, Vrashabh V. Sugandhi, Chandrakantsing V. Pardeshi, Rahul Jaywant Patil, Mit Joshi, Bhoomika Patel, Avinash Khadela, Rajashri Bezbaruah, Bedanta Bhattacharjee, Pankti C. Balar, Lalitkumar K. Vora^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

106 Downloads (Pure)

Abstract

Exosomes are multivesicular bodies of which the plasma membrane fuse to release the caring moiety into the surrounding body fluids. They are well knwon for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell to another. These “naturally equipped” nanovesicles could be therapeutically targeted or engineered as drug delivery systems. The use of exosomes in cancer detection and prognosis has attracted a great deal of interest from academics. In addition to chemical, biological, and genetic engineering approaches, other current exosomal alteration methodologies hold promise for the advancement of therapeutic medicines for cancer. In this review, we highlight the theranostic potential of exosomes for therapeutic delivery in various cancers.

Original language	English
Article number	104579
Number of pages	17
Journal	Journal of Drug Delivery Science and Technology
Volume	85
Early online date	24 May 2023
DOIs	https://doi.org/10.1016/j.jddst.2023.104579
Publication status	Published - Aug 2023

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10.1016/j.jddst.2023.104579Licence: CC BY

Engineered exosomes for cancer theranostics: next-generation tumor targeting
Copyright 2023 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 4.83 MBLicence: CC BY

Cite this

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title = "Engineered exosomes for cancer theranostics: next-generation tumor targeting",

abstract = "Exosomes are multivesicular bodies of which the plasma membrane fuse to release the caring moiety into the surrounding body fluids. They are well knwon for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell to another. These “naturally equipped” nanovesicles could be therapeutically targeted or engineered as drug delivery systems. The use of exosomes in cancer detection and prognosis has attracted a great deal of interest from academics. In addition to chemical, biological, and genetic engineering approaches, other current exosomal alteration methodologies hold promise for the advancement of therapeutic medicines for cancer. In this review, we highlight the theranostic potential of exosomes for therapeutic delivery in various cancers.",

author = "Chavda, {Vivek P.} and Sugandhi, {Vrashabh V.} and Pardeshi, {Chandrakantsing V.} and Patil, {Rahul Jaywant} and Mit Joshi and Bhoomika Patel and Avinash Khadela and Rajashri Bezbaruah and Bedanta Bhattacharjee and Balar, {Pankti C.} and Vora, {Lalitkumar K.}",

year = "2023",

month = aug,

doi = "10.1016/j.jddst.2023.104579",

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T1 - Engineered exosomes for cancer theranostics: next-generation tumor targeting

AU - Chavda, Vivek P.

AU - Sugandhi, Vrashabh V.

AU - Pardeshi, Chandrakantsing V.

AU - Patil, Rahul Jaywant

AU - Joshi, Mit

AU - Patel, Bhoomika

AU - Khadela, Avinash

AU - Bezbaruah, Rajashri

AU - Bhattacharjee, Bedanta

AU - Balar, Pankti C.

AU - Vora, Lalitkumar K.

PY - 2023/8

Y1 - 2023/8

N2 - Exosomes are multivesicular bodies of which the plasma membrane fuse to release the caring moiety into the surrounding body fluids. They are well knwon for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell to another. These “naturally equipped” nanovesicles could be therapeutically targeted or engineered as drug delivery systems. The use of exosomes in cancer detection and prognosis has attracted a great deal of interest from academics. In addition to chemical, biological, and genetic engineering approaches, other current exosomal alteration methodologies hold promise for the advancement of therapeutic medicines for cancer. In this review, we highlight the theranostic potential of exosomes for therapeutic delivery in various cancers.

AB - Exosomes are multivesicular bodies of which the plasma membrane fuse to release the caring moiety into the surrounding body fluids. They are well knwon for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell to another. These “naturally equipped” nanovesicles could be therapeutically targeted or engineered as drug delivery systems. The use of exosomes in cancer detection and prognosis has attracted a great deal of interest from academics. In addition to chemical, biological, and genetic engineering approaches, other current exosomal alteration methodologies hold promise for the advancement of therapeutic medicines for cancer. In this review, we highlight the theranostic potential of exosomes for therapeutic delivery in various cancers.

U2 - 10.1016/j.jddst.2023.104579

DO - 10.1016/j.jddst.2023.104579

M3 - Review article

SN - 1773-2247

VL - 85

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

M1 - 104579

ER -

Engineered exosomes for cancer theranostics: next-generation tumor targeting

Abstract

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