Engineered Spider Silk Protein-Based Composites for Drug Delivery

John G. Hardy, Aldo Leal-Egana, Thomas R. Scheibel*

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Citations (Scopus)
305 Downloads (Pure)

Abstract

Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.

Original languageEnglish
Pages (from-to)1431-1437
Number of pages7
JournalMacromolecular bioscience
Volume13
Issue number10
Early online date23 Jul 2013
DOIs
Publication statusPublished - Oct 2013
Externally publishedYes

Keywords

  • biodegradable biomaterials
  • coatings
  • composites
  • drug delivery
  • IN-VITRO
  • BIOMEDICAL APPLICATIONS
  • BIODEGRADABLE POLYMERS
  • L-ALANINE
  • BIOMATERIALS
  • POLYURETHANES
  • SURFACES
  • VIVO
  • ADHESION
  • FIBROIN

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)

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