Engineered Spider Silk Protein-Based Composites for Drug Delivery

John G. Hardy; Aldo Leal-Egana; Thomas R. Scheibel

doi:10.1002/mabi.201300233

Engineered Spider Silk Protein-Based Composites for Drug Delivery

John G. Hardy, Aldo Leal-Egana, Thomas R. Scheibel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

2674 Downloads (Pure)

Abstract

Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.

Original language	English
Pages (from-to)	1431-1437
Number of pages	7
Journal	Macromolecular Bioscience
Volume	13
Issue number	10
Early online date	23 Jul 2013
DOIs	https://doi.org/10.1002/mabi.201300233
Publication status	Published - Oct 2013
Externally published	Yes

Keywords

biodegradable biomaterials
coatings
composites
drug delivery
IN-VITRO
BIOMEDICAL APPLICATIONS
BIODEGRADABLE POLYMERS
L-ALANINE
BIOMATERIALS
POLYURETHANES
SURFACES
VIVO
ADHESION
FIBROIN

ASJC Scopus subject areas

Biomaterials
General Chemistry

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10.1002/mabi.201300233

Engineered Spider Silk Protein-Based Composites for Drug Delivery
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim This is the peer reviewed version of the following article: Hardy, JG, Leal-Egana, A & Scheibel, TR 2013, 'Engineered Spider Silk Protein-Based Composites for Drug Delivery' Macromolecular bioscience, vol 13, no. 10, pp. 1431-1437, which has been published in final form at 10.1002/mabi.201300233. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 1.39 MB

Cite this

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title = "Engineered Spider Silk Protein-Based Composites for Drug Delivery",

abstract = "Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.",

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year = "2013",

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TY - JOUR

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AU - Hardy, John G.

AU - Leal-Egana, Aldo

AU - Scheibel, Thomas R.

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Y1 - 2013/10

N2 - Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.

AB - Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.

KW - biodegradable biomaterials

KW - coatings

KW - composites

KW - drug delivery

KW - IN-VITRO

KW - BIOMEDICAL APPLICATIONS

KW - BIODEGRADABLE POLYMERS

KW - L-ALANINE

KW - BIOMATERIALS

KW - POLYURETHANES

KW - SURFACES

KW - VIVO

KW - ADHESION

KW - FIBROIN

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JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 10

ER -

Engineered Spider Silk Protein-Based Composites for Drug Delivery

Abstract

Keywords

ASJC Scopus subject areas

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