Engineering and manufacturing of pharmaceutical co-crystals: A review of solvent-free manufacturing technologies

S. A. Ross, D. A. Lamprou*, D. Douroumis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

74 Citations (Scopus)
372 Downloads (Pure)

Abstract

Design and synthesis of pharmaceutical cocrystals have received great interest in recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and pharmacological properties such as solubility, stability, hydroscopicity, dissolution rates and bioavailability. It is now possible to engineer and develop cocrystals via 'green chemistry' and environmentally friendly approaches such as solid-state synthesis in the absence of organic solvents. In addition, significant efforts have been directed towards computational screening, cocrystal manufacturing in a continuous manner and real-time monitoring for quality purposes by using various analytical tools. Pharmaceutical cocrystals are not fully exploited yet and there is a lot of ground to cover before they can be successfully utilized as medical products.

Original languageEnglish
Pages (from-to)8772-8786
JournalChemical Communications
Volume52
Issue number57
Early online date27 May 2016
DOIs
Publication statusEarly online date - 27 May 2016
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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